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dc.contributor.authorLim, L
dc.contributor.authorSayers, CP
dc.contributor.authorGoodman, CD
dc.contributor.authorMcFadden, GI
dc.date.accessioned2021-02-04T01:53:29Z
dc.date.available2021-02-04T01:53:29Z
dc.date.issued2016-07-21
dc.identifierpii: PONE-D-16-15265
dc.identifier.citationLim, L., Sayers, C. P., Goodman, C. D. & McFadden, G. I. (2016). Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum. PLOS ONE, 11 (7), https://doi.org/10.1371/journal.pone.0159603.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/259509
dc.description.abstractApicoplasts are vestigial plastids in apicomplexan parasites like Plasmodium, the causative agent of malaria. Apicomplexan parasites are dependant on their apicoplasts for synthesis of various molecules that they are unable to scavenge in sufficient quantity from their host, which makes apicoplasts attractive drug targets. Proteins known as plastid phosphate translocators (pPTs) are embedded in the outer apicoplast membrane and are responsible for the import of carbon, energy and reducing power to drive anabolic synthesis in the organelle. We investigated how a pPT is targeted into the outer apicoplast membrane of the human malaria parasite P. falciparum. We showed that a transmembrane domain is likely to act as a recessed signal anchor to direct the protein into the endomembrane system, and that a tyrosine in the cytosolic N-terminus of the protein is essential for targeting, but one or more, as yet unidentified, factors are also essential to direct the protein into the outer apicoplast membrane.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTargeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0159603
melbourne.affiliation.departmentSchool of BioSciences
melbourne.affiliation.facultyScience
melbourne.source.titlePLoS One
melbourne.source.volume11
melbourne.source.issue7
melbourne.identifier.arcDP130103236
dc.rights.licenseCC BY
melbourne.elementsid1082491
melbourne.contributor.authorGoodman, Christopher
melbourne.contributor.authorSayers, Claire
melbourne.contributor.authorMcFadden, Geoffrey
melbourne.contributor.authorLIM, LITING
dc.identifier.eissn1932-6203
melbourne.identifier.fundernameidAUST RESEARCH COUNCIL, DP130103236
melbourne.accessrightsOpen Access


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