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    Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets

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    Author
    Schultze-Lutter, F; Debbane, M; Theodoridou, A; Wood, SJ; Raballo, A; Michel, C; Schmidt, SJ; Kindler, J; Ruhrmann, S; Uhlhaas, PJ
    Date
    2016-01-28
    Source Title
    Frontiers in Psychiatry
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Wood, Stephen
    Affiliation
    Centre for Youth Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Schultze-Lutter, F., Debbane, M., Theodoridou, A., Wood, S. J., Raballo, A., Michel, C., Schmidt, S. J., Kindler, J., Ruhrmann, S. & Uhlhaas, P. J. (2016). Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets. FRONTIERS IN PSYCHIATRY, 7 (JAN), https://doi.org/10.3389/fpsyt.2016.00009.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259528
    DOI
    10.3389/fpsyt.2016.00009
    Abstract
    In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self-experienced expression of the underlying neurobiological aberrations of the disease. Other characteristic symptoms of psychosis (e.g., delusions and hallucinations) were conceptualized as secondary phenomena, resulting from dysfunctional beliefs and suboptimal coping styles with emerging BSs and/or concomitant stressors. While BSs can occur in many mental disorders, in particular affective disorders, a subset of perceptive and cognitive BSs appear to be specific to psychosis and are currently employed in two alternative risk criteria. However, despite their clinical recognition in the early detection of psychosis, neurobiological research on the aetiopathology of psychosis with neuroimaging methods has only just begun to consider the neural correlate of BSs. This perspective paper reviews the emerging evidence of an association between BSs and aberrant brain activation, connectivity patterns, and metabolism, and outlines promising routes for the use of BSs in aetiopathological research on psychosis.

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