Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets

Download
Author
Schultze-Lutter, F; Debbane, M; Theodoridou, A; Wood, SJ; Raballo, A; Michel, C; Schmidt, SJ; Kindler, J; Ruhrmann, S; Uhlhaas, PJDate
2016-01-28Source Title
Frontiers in PsychiatryPublisher
FRONTIERS MEDIA SAUniversity of Melbourne Author/s
Wood, StephenAffiliation
Centre for Youth Mental HealthMetadata
Show full item recordDocument Type
Journal ArticleCitations
Schultze-Lutter, F., Debbane, M., Theodoridou, A., Wood, S. J., Raballo, A., Michel, C., Schmidt, S. J., Kindler, J., Ruhrmann, S. & Uhlhaas, P. J. (2016). Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets. FRONTIERS IN PSYCHIATRY, 7 (JAN), https://doi.org/10.3389/fpsyt.2016.00009.Access Status
Open AccessAbstract
In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self-experienced expression of the underlying neurobiological aberrations of the disease. Other characteristic symptoms of psychosis (e.g., delusions and hallucinations) were conceptualized as secondary phenomena, resulting from dysfunctional beliefs and suboptimal coping styles with emerging BSs and/or concomitant stressors. While BSs can occur in many mental disorders, in particular affective disorders, a subset of perceptive and cognitive BSs appear to be specific to psychosis and are currently employed in two alternative risk criteria. However, despite their clinical recognition in the early detection of psychosis, neurobiological research on the aetiopathology of psychosis with neuroimaging methods has only just begun to consider the neural correlate of BSs. This perspective paper reviews the emerging evidence of an association between BSs and aberrant brain activation, connectivity patterns, and metabolism, and outlines promising routes for the use of BSs in aetiopathological research on psychosis.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References