Show simple item record

dc.contributor.authorZhang, X
dc.contributor.authorSun, H
dc.contributor.authorPaul, SK
dc.contributor.authorWang, Q
dc.contributor.authorLou, X
dc.contributor.authorHou, G
dc.contributor.authorWen, B
dc.contributor.authorJi, L
dc.contributor.authorLiu, S
dc.date.accessioned2021-02-04T01:58:20Z
dc.date.available2021-02-04T01:58:20Z
dc.date.issued2017-05-17
dc.identifierpii: 9154
dc.identifier.citationZhang, X., Sun, H., Paul, S. K., Wang, Q., Lou, X., Hou, G., Wen, B., Ji, L. & Liu, S. (2017). The serum protein responses to treatment with Xiaoke Pill and Glibenclamide in type 2 diabetes patients. CLINICAL PROTEOMICS, 14 (1), https://doi.org/10.1186/s12014-017-9154-0.
dc.identifier.issn1542-6416
dc.identifier.urihttp://hdl.handle.net/11343/259535
dc.description.abstractAIM: The Xiaoke Pill containing Chinese herb extracts and Glibenclamide, is used in therapy for type 2 diabetes mellitus (T2DM), and is effective in reducing the risk of hypoglycemia and improving diabetes symptoms compared with Glibenclamide. We describe a quantitative proteomics project to measure the T2DM serum proteome response to the Xiaoke Pill and Glibenclamide. METHODS: Based on a recently conducted 48-week clinical trial comparing the safety and efficacy of Glibenclamide (n = 400) and Xiaoke Pill (n = 400), after matching for age, sex, BMI, drug dose and whether hypoglycemia occurred, 32 patients were selected for the serum based proteomic analysis and divided into four groups (with/without hypoglycemia treated with Xiaoke Pill or Glibenclamide, n = 8 for each group). We screened the differential serum proteins related to treatments and the onset of hypoglycemia using the iTRAQ labeling quantitative proteomics technique. Baseline and follow-up samples were used. RESULTS: The quantitative proteomics experiments demonstrated that 25 and 21 proteins differed upon treatment with the Xiaoke Pill in patients without and with hypoglycemia, respectively, while 24 and 25 proteins differed upon treatment with Glibenclamide in patients without and with hypoglycemia, respectively. The overlap of different proteins between the patients with and without hypoglycemia given the same drug treatment was much greater than between the patients given different drug treatments. CONCLUSIONS: We conclude that the serum proteins response to the two different anti-diabetic drug treatments may serve as a sensitive biomarker for evaluation of the therapeutic effects and continue investigations into the mechanism.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe serum protein responses to treatment with Xiaoke Pill and Glibenclamide in type 2 diabetes patients
dc.typeJournal Article
dc.identifier.doi10.1186/s12014-017-9154-0
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleClinical Proteomics
melbourne.source.volume14
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1214612
melbourne.contributor.authorPaul, Sanjoy
dc.identifier.eissn1559-0275
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record