Whole-brain patterns of H-1-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies
AuthorSu, L; Blamire, AM; Watson, R; He, J; Hayes, L; O'Brien, JT
Source TitleTranslational Psychiatry
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sWatson, Rosemary
Document TypeJournal Article
CitationsSu, L., Blamire, A. M., Watson, R., He, J., Hayes, L. & O'Brien, J. T. (2016). Whole-brain patterns of H-1-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies. TRANSLATIONAL PSYCHIATRY, 6 (8), https://doi.org/10.1038/tp.2016.140.
Access StatusOpen Access
Magnetic resonance spectroscopy has demonstrated metabolite changes in neurodegenerative disorders such as Alzheimer's disease (AD) and dementia with Lewy bodies (DLB); however, their pattern and relationship to clinical symptoms is unclear. To determine whether the spatial patterns of brain-metabolite changes in AD and DLB are regional or diffused, and to examine whether the key metabolite levels are associated with cognitive and non-cognitive symptoms, we acquired whole-brain spatially resolved 3T magnetic resonance spectroscopic imaging (MRSI) data from subjects with AD (N=36), DLB (N=35) and similarly aged controls (N=35). Voxel-wise measurement of N-acetylaspartate to creatine (NAA/Cr), choline to Cr (Cho/Cr), myo-inositol to Cr (mI/Cr) as well as glutamate and glutamine to Cr (Glx/Cr) ratios were determined using MRSI. Compared with controls, AD and DLB groups showed a significant decrease in most brain metabolites, with NAA/Cr, Cho/Cr and mI/Cr levels being reduced in posterior cingulate, thalamus, frontotemporal areas and basal ganglia. The Glx/Cr level was more widely decreased in DLB (posterior cingulate, hippocampus, temporal regions and caudate) than in AD (only in posterior cingulate). DLB was also associated with increased levels of Cho/Cr, NAA/Cr and mI/Cr in occipital regions. Changes in metabolism in the brain were correlated with cognitive and non-cognitive symptoms in the DLB but not in the AD group. The different patterns between AD and DLB may have implications for improving diagnosis, better understanding disease-specific neurobiology and targeting therapeutics. In addition, the study raised important questions about the role of occipital neuroinflammation and glial activation as well as the glutamatergic treatment in DLB.
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