Show simple item record

dc.contributor.authorDendle, C
dc.contributor.authorGilbertson, M
dc.contributor.authorSpelman, T
dc.contributor.authorStuart, RL
dc.contributor.authorKorman, TM
dc.contributor.authorThursky, K
dc.contributor.authorOpat, S
dc.contributor.authorMcQuilten, Z
dc.date.accessioned2021-02-04T02:11:40Z
dc.date.available2021-02-04T02:11:40Z
dc.date.issued2017-06-30
dc.identifierpii: 10.1038/s41598-017-04495-x
dc.identifier.citationDendle, C., Gilbertson, M., Spelman, T., Stuart, R. L., Korman, T. M., Thursky, K., Opat, S. & McQuilten, Z. (2017). Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-04495-x.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/259603
dc.description.abstractTo identify risk factors for infection in patients with diffuse large B cell lymphoma (DLBCL) undergoing rituximab, cyclophosphamide, vincristine, adriamycin and prednisolone (R-CHOP) treatment. All patients with DLBCL who received R-CHOP from 2004-2014 in a tertiary Australian hospital were identified and information collected from hospital admission data, laboratory results and medical record review. Infection was defined as hospitalisation with an ICD-10-AM diagnostic code for infection. Risk factors for infection and association between infection and survival were modelled using Cox proportional hazards regression. Over the 10-year period there were 325 patients; 191 (58.8%) males, median age 66 years. 206 (63.4%) patients experienced ≥1 infection. Independent predictors of infection were Charlson comorbidity index score (hazard ratio [HR] 3.60, p = 0.002), Eastern Cooperative Oncology Group (ECOG) performance status (HR 2.09 p = <0.001) and neutropenia (HR 2.46, p = <0.001). 99 (31%) patients died. Infection was an independent predictor of survival (HR 3.27, p = <0.001, as were age (HR 2.49, p = 0.001), Charlson comorbidity index (HR 4.34, p = <0.001), ECOG performance status (HR 4.33, p = 0.045) and neutropenia (HR 1.95, p = 0.047). Infections are common and infection itself is an independent predictor of survival. Patients at highest risk of infection and death are those with multiple comorbidities, poor performance status and neutropenia.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInfection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-017-04495-x
melbourne.affiliation.departmentInfectious Diseases
melbourne.affiliation.departmentSurgery (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1219161
melbourne.contributor.authorThursky, Karin
melbourne.contributor.authorSpelman, Timothy
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record