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dc.contributor.authorChow, EPF
dc.contributor.authorWalker, S
dc.contributor.authorHocking, JS
dc.contributor.authorBradshaw, CS
dc.contributor.authorChen, MY
dc.contributor.authorTabrizi, SN
dc.contributor.authorHowden, BP
dc.contributor.authorLaw, MG
dc.contributor.authorMaddaford, K
dc.contributor.authorRead, TRH
dc.contributor.authorLewis, DA
dc.contributor.authorWhiley, DM
dc.contributor.authorZhang, L
dc.contributor.authorGrulich, AE
dc.contributor.authorKaldor, JM
dc.contributor.authorCornelisse, VJ
dc.contributor.authorPhillips, S
dc.contributor.authorDonovan, B
dc.contributor.authorMcNulty, AM
dc.contributor.authorTempleton, DJ
dc.contributor.authorRoth, N
dc.contributor.authorMoore, R
dc.contributor.authorFairley, CK
dc.date.accessioned2021-02-04T02:17:11Z
dc.date.available2021-02-04T02:17:11Z
dc.date.issued2017-06-28
dc.identifierpii: 10.1186/s12879-017-2541-3
dc.identifier.citationChow, E. P. F., Walker, S., Hocking, J. S., Bradshaw, C. S., Chen, M. Y., Tabrizi, S. N., Howden, B. P., Law, M. G., Maddaford, K., Read, T. R. H., Lewis, D. A., Whiley, D. M., Zhang, L., Grulich, A. E., Kaldor, J. M., Cornelisse, V. J., Phillips, S., Donovan, B., McNulty, A. M. ,... Fairley, C. K. (2017). A multicentre double-blind randomised controlled trial evaluating the efficacy of daily use of antibacterial mouthwash against oropharyngeal gonorrhoea among men who have sex with men: the OMEGA (Oral Mouthwash use to Eradicate GonorrhoeA) study protocol. BMC INFECTIOUS DISEASES, 17 (1), https://doi.org/10.1186/s12879-017-2541-3.
dc.identifier.issn1471-2334
dc.identifier.urihttp://hdl.handle.net/11343/259637
dc.description.abstractBACKGROUND: Gonorrhoea is one of the most common sexually transmissible infections in men who have sex with men (MSM). Gonorrhoea rates have increased substantially in recent years. There is concern that increasing gonorrhoea prevalence will increase the likelihood of worsening antibiotic resistance in Neisseria gonorrhoeae. A recent randomised controlled trial (RCT) demonstrated that a single-dose of mouthwash has an inhibitory effect against oropharyngeal gonorrhoea. We are conducting the first RCT to evaluate whether daily use of mouthwash could reduce the risk of acquiring oropharyngeal gonorrhoea. METHODS/DESIGN: The OMEGA (Oral Mouthwash use to Eradicate GonorrhoeA) study is a double-blind RCT and will be conducted at several sexual health clinics and high caseload General Practice (GP) clinics in Melbourne and Sydney, Australia. A total of 504 MSM attending the participating sites will be recruited. Participants will be randomised to either using 'Study mouthwash A' or 'Study mouthwash B' for 12 weeks. Study mouthwash A was inhibitory against N. gonorrhoeae in vitro, whereas study mouthwash B was not. Participants will be instructed to rinse and gargle the study mouthwash for 60 seconds every day. The primary outcome is the proportion of participants with oropharyngeal gonorrhoea detected by nucleic acid amplification test by 12 weeks. DISCUSSION: The results from this trial may provide a novel way to reduce gonorrhoea prevalence and transmission without the use of antibiotics that may be associated with development of resistance. If shown to be effective, the widespread use of mouthwash will reduce the prevalence of oropharyngeal gonorrhoea, which plays key role in driving the emergence of gonococcal antimicrobial resistance through DNA exchange with oral commensal bacteria. The anticipated net effect will be interruption of onward transmission of N. gonorrhoeae within high density sexual networks within MSM populations. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12616000247471 , registered on 23rd February 2016.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleA multicentre double-blind randomised controlled trial evaluating the efficacy of daily use of antibacterial mouthwash against oropharyngeal gonorrhoea among men who have sex with men: the OMEGA (Oral Mouthwash use to Eradicate GonorrhoeA) study protocol
dc.typeJournal Article
dc.identifier.doi10.1186/s12879-017-2541-3
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleBMC Infectious Diseases
melbourne.source.volume17
melbourne.source.issue1
melbourne.identifier.nhmrc1105905
dc.rights.licenseCC BY
melbourne.elementsid1216966
melbourne.contributor.authorHocking, Jane
melbourne.contributor.authorHowden, Benjamin
melbourne.contributor.authorTabrizi, Sepehr
melbourne.contributor.authorBradshaw, Catriona
melbourne.contributor.authorChen, Marcus
melbourne.contributor.authorChow, Eric
dc.identifier.eissn1471-2334
melbourne.identifier.fundernameidNHMRC, 1105905
melbourne.accessrightsOpen Access


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