Building connectomes using diffusion MRI: why, how and but

Download
Author
Sotiropoulos, SN; Zalesky, ADate
2019-04-01Source Title
NMR in BiomedicinePublisher
WILEYUniversity of Melbourne Author/s
Zalesky, AndrewAffiliation
PsychiatryMetadata
Show full item recordDocument Type
Journal ArticleCitations
Sotiropoulos, S. N. & Zalesky, A. (2019). Building connectomes using diffusion MRI: why, how and but. NMR IN BIOMEDICINE, 32 (4), https://doi.org/10.1002/nbm.3752.Access Status
Open AccessDOI
10.1002/nbm.3752NHMRC Grant code
NHMRC/1047648Abstract
Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, fiber tracking algorithms and other methodological choices affect connectome estimation? What are the main factors that dictate the success and failure of connectome reconstruction? These are some of the key questions that we aim to address in this review. We provide an overview of the key methods that can be used to estimate the nodes and edges of macroscale connectomes, and we discuss open problems and inherent limitations. We argue that diffusion MRI-based connectome mapping methods are still in their infancy and caution against blind application of deep white matter tractography due to the challenges inherent to connectome reconstruction. We review a number of studies that provide evidence of useful microstructural and network properties that can be extracted in various independent and biologically relevant contexts. Finally, we highlight some of the key deficiencies of current macroscale connectome mapping methodologies and motivate future developments.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References
Collections
- Minerva Elements Records [52443]
- Psychiatry - Research Publications [1373]