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dc.contributor.authorPastor, WA
dc.contributor.authorStroud, H
dc.contributor.authorNee, K
dc.contributor.authorLiu, W
dc.contributor.authorPezic, D
dc.contributor.authorManakov, S
dc.contributor.authorLee, SA
dc.contributor.authorMoissiard, G
dc.contributor.authorZamudio, N
dc.contributor.authorBourc'his, D
dc.contributor.authorAravin, AA
dc.contributor.authorClark, AT
dc.contributor.authorJacobsen, SE
dc.date.accessioned2021-02-04T02:19:56Z
dc.date.available2021-02-04T02:19:56Z
dc.date.issued2014-12-01
dc.identifierpii: ncomms6795
dc.identifier.citationPastor, W. A., Stroud, H., Nee, K., Liu, W., Pezic, D., Manakov, S., Lee, S. A., Moissiard, G., Zamudio, N., Bourc'his, D., Aravin, A. A., Clark, A. T. & Jacobsen, S. E. (2014). MORC1 represses transposable elements in the mouse male germline. NATURE COMMUNICATIONS, 5 (1), https://doi.org/10.1038/ncomms6795.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/259646
dc.description.abstractThe Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of largely unknown function. Genetic screens in Arabidopsis thaliana have identified Morc genes as important repressors of transposons and other DNA-methylated and silent genes. MORC1-deficient mice were previously found to display male-specific germ cell loss and infertility. Here we show that MORC1 is responsible for transposon repression in the male germline in a pattern that is similar to that observed for germ cells deficient for the DNA methyltransferase homologue DNMT3L. Morc1 mutants show highly localized defects in the establishment of DNA methylation at specific classes of transposons, and this is associated with failed transposon silencing at these sites. Our results identify MORC1 as an important new regulator of the epigenetic landscape of male germ cells during the period of global de novo methylation.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleMORC1 represses transposable elements in the mouse male germline
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms6795
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume5
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1219180
melbourne.contributor.authorZamudio, Natasha
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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