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dc.contributor.authorMaetens, M
dc.contributor.authorBrown, D
dc.contributor.authorIrrthum, A
dc.contributor.authorAftimos, P
dc.contributor.authorViale, G
dc.contributor.authorLoibl, S
dc.contributor.authorLaes, J-F
dc.contributor.authorCampbell, PJ
dc.contributor.authorThompson, A
dc.contributor.authorCortes, J
dc.contributor.authorSeiler, S
dc.contributor.authorVinnicombe, S
dc.contributor.authorOliveira, M
dc.contributor.authorRothe, F
dc.contributor.authorBareche, Y
dc.contributor.authorFumagalli, D
dc.contributor.authorZardavas, D
dc.contributor.authorDesmedt, C
dc.contributor.authorPiccart, M
dc.contributor.authorLoi, S
dc.contributor.authorSotiriou, C
dc.date.accessioned2021-02-04T02:25:33Z
dc.date.available2021-02-04T02:25:33Z
dc.date.issued2017-06-29
dc.identifierpii: 26
dc.identifier.citationMaetens, M., Brown, D., Irrthum, A., Aftimos, P., Viale, G., Loibl, S., Laes, J. -F., Campbell, P. J., Thompson, A., Cortes, J., Seiler, S., Vinnicombe, S., Oliveira, M., Rothe, F., Bareche, Y., Fumagalli, D., Zardavas, D., Desmedt, C., Piccart, M. ,... Sotiriou, C. (2017). The AURORA pilot study for molecular screening of patients with advanced breast cancer-a study of the breast international group. NPJ BREAST CANCER, 3 (1), https://doi.org/10.1038/s41523-017-0026-6.
dc.identifier.issn2374-4677
dc.identifier.urihttp://hdl.handle.net/11343/259675
dc.description.abstractSeveral studies have demonstrated the feasibility of molecular screening of tumour samples for matching patients with cancer to targeted therapies. However, most of them have been carried out at institutional or national level. Herein, we report on the pilot phase of AURORA (NCT02102165), a European multinational collaborative molecular screening initiative for advanced breast cancer patients. Forty-one patients were prospectively enroled at four participating centres across Europe. Metastatic tumours were biopsied and profiled using an Ion Torrent sequencing platform at a central facility. Sequencing results were obtained for 63% of the patients in real-time with variable turnaround time stemming from delays between patient consent and biopsy. At least one clinically actionable mutation was identified in 73% of patients. We used the Illumina sequencing technology for orthogonal validation and achieved an average of 66% concordance of substitution calls per patient. Additionally, copy number aberrations inferred from the Ion Torrent sequencing were compared to single nucleotide polymorphism arrays and found to be 59% concordant on average. Although this study demonstrates that powerful next generation genomic techniques are logistically ready for international molecular screening programs in routine clinical settings, technical challenges remain to be addressed in order to ensure the accuracy and clinical utility of the genomic data.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleThe AURORA pilot study for molecular screening of patients with advanced breast cancer-a study of the breast international group
dc.typeJournal Article
dc.identifier.doi10.1038/s41523-017-0026-6
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.facultyCollected Works
melbourne.source.titlenpj Breast Cancer
melbourne.source.volume3
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1221595
melbourne.contributor.authorLoi, Sherene
dc.identifier.eissn2374-4677
melbourne.accessrightsOpen Access


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