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    Predictive Molecular Tumour Testing: What Are the Obstacles between Bench and Bedside?

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    Author
    Mileshkin, L; Shah, B; Michael, M
    Date
    2012
    Source Title
    Chemotherapy Research and Practice
    Publisher
    Hindawi Limited
    University of Melbourne Author/s
    Mileshkin, Linda; Michael, Michael
    Affiliation
    Medical Education
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Mileshkin, L., Shah, B. & Michael, M. (2012). Predictive Molecular Tumour Testing: What Are the Obstacles between Bench and Bedside?. Chemother Res Pract, 2012, pp.838509-. https://doi.org/10.1155/2012/838509.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259976
    DOI
    10.1155/2012/838509
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359779
    Abstract
    There have been many exciting new breakthroughs in understanding tumour biology. This has opened up the possibility of personalized treatment for people with certain tumours. The epidermal growth factor receptor (EGFR) and K-ras are two such targets that can help classify tumours on a molecular basis and guide treatment decisions. However, there are still questions about how best to implement new molecular tests like these to characterize tumours in clinical practice. Potential obstacles include availability of good quality tissue specimens, access to the right test, and consensus about interpretation, funding, and availability. In this paper, we review these issues, by discussing these two examples in detail and suggest some actions for addressing potential barriers.

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