Which interventions offer best value for money in primary prevention of cardiovascular disease?
Web of Science
AuthorCobiac, LJ; Magnus, A; Lim, S; Barendregt, JJ; Carter, R; Vos, T
Source TitlePLoS One
PublisherPublic Library of Science (PLoS)
University of Melbourne Author/sCOBIAC, LINDA
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsCobiac, L. J., Magnus, A., Lim, S., Barendregt, J. J., Carter, R. & Vos, T. (2012). Which interventions offer best value for money in primary prevention of cardiovascular disease?. PLoS One, 7 (7), pp.e41842-. https://doi.org/10.1371/journal.pone.0041842.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402472
BACKGROUND: Despite many decades of declining mortality rates in the Western world, cardiovascular disease remains the leading cause of death worldwide. In this research we evaluate the optimal mix of lifestyle, pharmaceutical and population-wide interventions for primary prevention of cardiovascular disease. METHODS AND FINDINGS: In a discrete time Markov model we simulate the ischaemic heart disease and stroke outcomes and cost impacts of intervention over the lifetime of all Australian men and women, aged 35 to 84 years, who have never experienced a heart disease or stroke event. Best value for money is achieved by mandating moderate limits on salt in the manufacture of bread, margarine and cereal. A combination of diuretic, calcium channel blocker, ACE inhibitor and low-cost statin, for everyone with at least 5% five-year risk of cardiovascular disease, is also cost-effective, but lifestyle interventions aiming to change risky dietary and exercise behaviours are extremely poor value for money and have little population health benefit. CONCLUSIONS: There is huge potential for improving efficiency in cardiovascular disease prevention in Australia. A tougher approach from Government to mandating limits on salt in processed foods and reducing excessive statin prices, and a shift away from lifestyle counselling to more efficient absolute risk-based prescription of preventive drugs, could cut health care costs while improving population health.
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