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dc.contributor.authorBradstock, KF
dc.contributor.authorMorley, A
dc.contributor.authorByth, K
dc.contributor.authorSzer, J
dc.contributor.authorProsser, I
dc.contributor.authorCannell, P
dc.contributor.authorIrving, I
dc.contributor.authorSeymour, JF
dc.date.accessioned2021-02-05T00:23:18Z
dc.date.available2021-02-05T00:23:18Z
dc.date.issued2016-12-15
dc.identifierpii: S2451-8654(15)30063-6
dc.identifier.citationBradstock, K. F., Morley, A., Byth, K., Szer, J., Prosser, I., Cannell, P., Irving, I. & Seymour, J. F. (2016). Effects of intensive induction and consolidation chemotherapy with idarubicin and high dose cytarabine on minimal residual disease levels in newly diagnosed adult precursor-B acute lymphoblastic leukemia. CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, 4, pp.9-13. https://doi.org/10.1016/j.conctc.2016.06.004.
dc.identifier.issn2451-8654
dc.identifier.urihttp://hdl.handle.net/11343/259984
dc.description.abstractAn intensive induction regimen, consisting of idarubicin and high dose cytarabine, was assessed in 19 adult patients, median age 44 years, with newly diagnosed precursor-B acute lymphoblastic leukemia (ALL). Patients achieving a complete response (CR) were given an attenuated consolidation course. The primary endpoints were induction death rate and incidence of serious non-hematological toxicity. Grades 3-4 diarrhoea occurred in 47% of patients during induction. Two patients (11%) died during induction therapy, and 2 were withdrawn due to resistant disease or prolonged marrow hypoplasia. Fifteen patients achieved CR (79%), but levels of minimal residual disease (MRD) after induction were comparable with those previously observed using a modified pediatric protocol. Overall survival at 5 years was 36.8% while leukemia-free survival was 44.1%. An intensive AML protocol used in adults with ALL resulted in substantial toxicity and provided similar levels of cytoreduction to conventional ALL protocols, without improving long-term outcomes.
dc.languageEnglish
dc.publisherELSEVIER INC
dc.titleEffects of intensive induction and consolidation chemotherapy with idarubicin and high dose cytarabine on minimal residual disease levels in newly diagnosed adult precursor-B acute lymphoblastic leukemia
dc.typeJournal Article
dc.identifier.doi10.1016/j.conctc.2016.06.004
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.facultyCollected Works
melbourne.source.titleContemporary Clinical Trials Communications
melbourne.source.volume4
melbourne.source.pages9-13
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1080501
melbourne.contributor.authorSeymour, John
melbourne.contributor.authorSzer, Jeffrey
dc.identifier.eissn2451-8654
melbourne.accessrightsOpen Access


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