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dc.contributor.authorFookes, M
dc.contributor.authorSchroeder, GN
dc.contributor.authorLangridge, GC
dc.contributor.authorBlondel, CJ
dc.contributor.authorMammina, C
dc.contributor.authorConnor, TR
dc.contributor.authorSeth-Smith, H
dc.contributor.authorVernikos, GS
dc.contributor.authorRobinson, KS
dc.contributor.authorSanders, M
dc.contributor.authorPetty, NK
dc.contributor.authorKingsley, RA
dc.contributor.authorBaeumler, AJ
dc.contributor.authorNuccio, S-P
dc.contributor.authorContreras, I
dc.contributor.authorSantiviago, CA
dc.contributor.authorMaskell, D
dc.contributor.authorBarrow, P
dc.contributor.authorHumphrey, T
dc.contributor.authorNastasi, A
dc.contributor.authorRoberts, M
dc.contributor.authorFrankel, G
dc.contributor.authorParkhill, J
dc.contributor.authorDougan, G
dc.contributor.authorThomson, NR
dc.date.accessioned2021-02-05T00:30:06Z
dc.date.available2021-02-05T00:30:06Z
dc.date.issued2011-08-01
dc.identifierpii: PPATHOGENS-D-10-00381
dc.identifier.citationFookes, M., Schroeder, G. N., Langridge, G. C., Blondel, C. J., Mammina, C., Connor, T. R., Seth-Smith, H., Vernikos, G. S., Robinson, K. S., Sanders, M., Petty, N. K., Kingsley, R. A., Baeumler, A. J., Nuccio, S. -P., Contreras, I., Santiviago, C. A., Maskell, D., Barrow, P., Humphrey, T. ,... Thomson, N. R. (2011). Salmonella bongori Provides Insights into the Evolution of the Salmonellae. PLOS PATHOGENS, 7 (8), https://doi.org/10.1371/journal.ppat.1002191.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/260031
dc.description.abstractThe genus Salmonella contains two species, S. bongori and S. enterica. Compared to the well-studied S. enterica there is a marked lack of information regarding the genetic makeup and diversity of S. bongori. S. bongori has been found predominantly associated with cold-blooded animals, but it can infect humans. To define the phylogeny of this species, and compare it to S. enterica, we have sequenced 28 isolates representing most of the known diversity of S. bongori. This cross-species analysis allowed us to confidently differentiate ancestral functions from those acquired following speciation, which include both metabolic and virulence-associated capacities. We show that, although S. bongori inherited a basic set of Salmonella common virulence functions, it has subsequently elaborated on this in a different direction to S. enterica. It is an established feature of S. enterica evolution that the acquisition of the type III secretion systems (T3SS-1 and T3SS-2) has been followed by the sequential acquisition of genes encoding secreted targets, termed effectors proteins. We show that this is also true of S. bongori, which has acquired an array of novel effector proteins (sboA-L). All but two of these effectors have no significant S. enterica homologues and instead are highly similar to those found in enteropathogenic Escherichia coli (EPEC). Remarkably, SboH is found to be a chimeric effector protein, encoded by a fusion of the T3SS-1 effector gene sopA and a gene highly similar to the EPEC effector nleH from enteropathogenic E. coli. We demonstrate that representatives of these new effectors are translocated and that SboH, similarly to NleH, blocks intrinsic apoptotic pathways while being targeted to the mitochondria by the SopA part of the fusion. This work suggests that S. bongori has inherited the ancestral Salmonella virulence gene set, but has adapted by incorporating virulence determinants that resemble those employed by EPEC.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSalmonella bongori Provides Insights into the Evolution of the Salmonellae
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1002191
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS Pathogens
melbourne.source.volume7
melbourne.source.issue8
dc.rights.licenseCC BY
melbourne.elementsid1081029
melbourne.contributor.authorDougan, Gordon
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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