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dc.contributor.authorLee, IR
dc.contributor.authorMolton, JS
dc.contributor.authorWyres, KL
dc.contributor.authorGorrie, C
dc.contributor.authorWong, J
dc.contributor.authorHoh, CH
dc.contributor.authorTeo, J
dc.contributor.authorKalimuddin, S
dc.contributor.authorLye, DC
dc.contributor.authorArchuleta, S
dc.contributor.authorHolt, KE
dc.contributor.authorGan, Y-H
dc.date.accessioned2021-02-05T00:31:08Z
dc.date.available2021-02-05T00:31:08Z
dc.date.issued2016-07-13
dc.identifierpii: srep29316
dc.identifier.citationLee, I. R., Molton, J. S., Wyres, K. L., Gorrie, C., Wong, J., Hoh, C. H., Teo, J., Kalimuddin, S., Lye, D. C., Archuleta, S., Holt, K. E. & Gan, Y. -H. (2016). Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep29316.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/260038
dc.description.abstractHypervirulent Klebsiella pneumoniae is an emerging cause of community-acquired pyogenic liver abscess. First described in Asia, it is now increasingly recognized in Western countries, commonly afflicting those with Asian descent. This raises the question of genetic predisposition versus geospecific strain acquisition. We leveraged on the Antibiotics for Klebsiella Liver Abscess Syndrome Study (A-KLASS) clinical trial ongoing in ethnically diverse Singapore, to prospectively examine the profiles of 70 patients together with their isolates' genotypic and phenotypic characteristics. The majority of isolates belonged to capsule type K1, a genetically homogenous group corresponding to sequence-type 23. The remaining K2, K5, K16, K28, K57 and K63 isolates as well as two novel cps isolates were genetically heterogeneous. K1 isolates carried higher frequencies of virulence-associated genes including rmpA (regulator of mucoid phenotype A), kfu (Klebsiella ferric uptake transporter), iuc (aerobactin), iro (salmochelin) and irp (yersiniabactin) than non-K1 isolates. The Chinese in our patient cohort, mostly non-diabetic, had higher prevalence of K1 infection than the predominantly diabetic non-Chinese (Malays, Indian and Caucasian). This differential susceptibility to different capsule types among the various ethnic groups suggests patterns of transmission (e.g. environmental source, familial transmission) and/or genetic predisposition unique to each race despite being in the same geographical location.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDifferential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population
dc.typeJournal Article
dc.identifier.doi10.1038/srep29316
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume6
melbourne.source.issue1
melbourne.identifier.nhmrc1061409
melbourne.identifier.nhmrc1043822
dc.rights.licenseCC BY
melbourne.elementsid1081967
melbourne.contributor.authorHolt, Kathryn
melbourne.contributor.authorWyres, Kelly
melbourne.contributor.authorGorrie, Claire
dc.identifier.eissn2045-2322
melbourne.identifier.fundernameidNHMRC, 1061409
melbourne.identifier.fundernameidNHMRC, 1043822
melbourne.accessrightsOpen Access


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