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dc.contributor.authorvan Velzen, LS
dc.contributor.authorSchmaal, L
dc.contributor.authorJansen, R
dc.contributor.authorMilaneschi, Y
dc.contributor.authorOpmeer, EM
dc.contributor.authorElzinga, BM
dc.contributor.authorvan der Wee, NJA
dc.contributor.authorVeltman, DJ
dc.contributor.authorPenninx, BWJH
dc.date.accessioned2021-02-05T00:35:02Z
dc.date.available2021-02-05T00:35:02Z
dc.date.issued2016-11-01
dc.identifierpii: nsw086
dc.identifier.citationvan Velzen, L. S., Schmaal, L., Jansen, R., Milaneschi, Y., Opmeer, E. M., Elzinga, B. M., van der Wee, N. J. A., Veltman, D. J. & Penninx, B. W. J. H. (2016). Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology. Social Cognitive and Affective Neuroscience, 11 (11), pp.1841-1852. https://doi.org/10.1093/scan/nsw086.
dc.identifier.issn1749-5016
dc.identifier.urihttp://hdl.handle.net/11343/260065
dc.description.abstractChildhood maltreatment (CM) has been associated with altered brain morphology, which may partly be due to a direct impact on neural growth, e.g. through the brain-derived neurotrophic factor (BDNF) pathway. Findings on CM, BDNF and brain volume are inconsistent and have never accounted for the entire BDNF pathway. We examined the effects of CM, BDNF (genotype, gene expression and protein level) and their interactions on hippocampus, amygdala and anterior cingulate cortex (ACC) morphology. Data were collected from patients with depression and/or an anxiety disorder and healthy subjects within the Netherlands Study of Depression and Anxiety (NESDA) (N = 289). CM was assessed using the Childhood Trauma Interview. BDNF Val66Met genotype, gene expression and serum protein levels were determined in blood and T1 MRI scans were acquired at 3T. Regional brain morphology was assessed using FreeSurfer. Covariate-adjusted linear regression analyses were performed. Amygdala volume was lower in maltreated individuals. This was more pronounced in maltreated met-allele carriers. The expected positive relationship between BDNF gene expression and volume of the amygdala is attenuated in maltreated subjects. Finally, decreased cortical thickness of the ACC was identified in maltreated subjects with the val/val genotype. CM was associated with altered brain morphology, partly in interaction with multiple levels of the BNDF pathway. Our results suggest that CM has different effects on brain morphology in met-carriers and val-homozygotes and that CM may disrupt the neuroprotective effect of BDNF.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEffect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology
dc.typeJournal Article
dc.identifier.doi10.1093/scan/nsw086
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleSocial Cognitive and Affective Neuroscience
melbourne.source.volume11
melbourne.source.issue11
melbourne.source.pages1841-1852
dc.rights.licenseCC BY
melbourne.elementsid1086899
melbourne.contributor.authorSchmaal, Lianne
melbourne.contributor.authorvan Velzen, Laura
dc.identifier.eissn1749-5024
melbourne.accessrightsOpen Access


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