The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Web of Science
AuthorYu, Y; Wang, C; Clare, S; Wang, J; Lee, S-C; Brandt, C; Burke, S; Lu, L; He, D; Jenkins, NA; ...
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sDougan, Gordon
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsYu, Y., Wang, C., Clare, S., Wang, J., Lee, S. -C., Brandt, C., Burke, S., Lu, L., He, D., Jenkins, N. A., Copeland, N. G., Dougan, G. & Liu, P. (2015). The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. JOURNAL OF EXPERIMENTAL MEDICINE, 212 (6), pp.865-874. https://doi.org/10.1084/jem.20142318.
Access StatusOpen Access
Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ∼28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.
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