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dc.contributor.authorYu, Y
dc.contributor.authorWang, C
dc.contributor.authorClare, S
dc.contributor.authorWang, J
dc.contributor.authorLee, S-C
dc.contributor.authorBrandt, C
dc.contributor.authorBurke, S
dc.contributor.authorLu, L
dc.contributor.authorHe, D
dc.contributor.authorJenkins, NA
dc.contributor.authorCopeland, NG
dc.contributor.authorDougan, G
dc.contributor.authorLiu, P
dc.date.accessioned2021-02-05T00:35:37Z
dc.date.available2021-02-05T00:35:37Z
dc.date.issued2015-06-01
dc.identifierpii: jem.20142318
dc.identifier.citationYu, Y., Wang, C., Clare, S., Wang, J., Lee, S. -C., Brandt, C., Burke, S., Lu, L., He, D., Jenkins, N. A., Copeland, N. G., Dougan, G. & Liu, P. (2015). The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. JOURNAL OF EXPERIMENTAL MEDICINE, 212 (6), pp.865-874. https://doi.org/10.1084/jem.20142318.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/260069
dc.description.abstractGroup 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ∼28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleThe transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20142318
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume212
melbourne.source.issue6
melbourne.source.pages865-874
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1089082
melbourne.contributor.authorDougan, Gordon
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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