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    Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period

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    Author
    McLean, ARD; Boel, ME; McGready, R; Ataide, R; Drew, D; Tsuboi, T; Beeson, JG; Nosten, F; Simpson, JA; Fowkes, FJI
    Date
    2016-08-25
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Beeson, James; Fowkes, Freya; Simpson, Julie; McLean, Alistair; Ataide, Ricardo
    Affiliation
    Medicine and Radiology
    Melbourne School of Population and Global Health
    Infectious Diseases
    Metadata
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    Document Type
    Journal Article
    Citations
    McLean, A. R. D., Boel, M. E., McGready, R., Ataide, R., Drew, D., Tsuboi, T., Beeson, J. G., Nosten, F., Simpson, J. A. & Fowkes, F. J. I. (2016). Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep32159.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260085
    DOI
    10.1038/srep32159
    Abstract
    During pregnancy a variety of immunological changes occur to accommodate the fetus. It is unknown whether these changes continue to affect humoral immunity postpartum or how quickly they resolve. IgG levels were measured to P. falciparum and P. vivax antigens in 201 postpartum and 201 controls over 12 weeks. Linear mixed-effects models assessed antibody maintenance over time and the effect of microscopically confirmed Plasmodium spp. infection on antibody levels, and whether this was different in postpartum women compared with control women. Postpartum women had reduced Plasmodium spp. antibody levels compared to controls at baseline. Over 12 weeks, mean antibody levels in postpartum women increased to levels observed in control women. Microscopically confirmed P. falciparum and P. vivax infections during follow-up were associated with an increase in species-specific antibodies with similar magnitudes of boosting observed in postpartum and control women. Antibodies specific for pregnancy-associated, VAR2CSA-expressing parasites did not rapidly decline postpartum and did not boost in response to infection in either postpartum or control women. After pregnancy, levels of malaria-specific antibodies were reduced, but recovered to levels seen in control women. There was no evidence of an impaired ability to mount a boosting response in postpartum women.

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