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    Bilateral retrobulbar optic neuropathy in the setting of interferon alpha-2a therapy.

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    Author
    Fuzzard, DRW; Mack, HG; Symons, RCA
    Date
    2014-05
    Source Title
    Case Reports in Ophthalmology
    Publisher
    S. Karger AG
    University of Melbourne Author/s
    Symons, Robert; Mack, Heather
    Affiliation
    Surgery (RMH)
    Ophthalmology (Eye & Ear Hospital)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Fuzzard, D. R. W., Mack, H. G. & Symons, R. C. A. (2014). Bilateral retrobulbar optic neuropathy in the setting of interferon alpha-2a therapy.. Case Rep Ophthalmol, 5 (2), pp.270-276. https://doi.org/10.1159/000366407.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260105
    DOI
    10.1159/000366407
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176402
    Abstract
    The development of biopharmaceutical agents, including the interferons (IFN), offers new treatment options for a wide range of medical conditions. Such advancements, however, have not come without risk to patients. Optic neuropathy in the setting of IFN therapy has been previously documented and is usually attributed to anterior ischaemic optic neuropathy; however, the pathophysiology remains poorly understood. Retrobulbar optic neuropathy associated with IFN treatment has not been described in the medical literature to date. We report the case of a 38-year-old Caucasian female with refractory acute myeloid leukaemia who developed painless bilateral blurred vision within 2 weeks of commencing a course of IFN alpha-2a. Extensive clinical workup demonstrated bilateral retrobulbar optic neuropathy. We report the clinical evaluation of this first documented case and discuss the possible aetiologies of her presentation.

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