Bilateral retrobulbar optic neuropathy in the setting of interferon alpha-2a therapy.
AuthorFuzzard, DRW; Mack, HG; Symons, RCA
Source TitleCase Reports in Ophthalmology
PublisherS. Karger AG
Ophthalmology (Eye & Ear Hospital)
Document TypeJournal Article
CitationsFuzzard, D. R. W., Mack, H. G. & Symons, R. C. A. (2014). Bilateral retrobulbar optic neuropathy in the setting of interferon alpha-2a therapy.. Case Rep Ophthalmol, 5 (2), pp.270-276. https://doi.org/10.1159/000366407.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176402
The development of biopharmaceutical agents, including the interferons (IFN), offers new treatment options for a wide range of medical conditions. Such advancements, however, have not come without risk to patients. Optic neuropathy in the setting of IFN therapy has been previously documented and is usually attributed to anterior ischaemic optic neuropathy; however, the pathophysiology remains poorly understood. Retrobulbar optic neuropathy associated with IFN treatment has not been described in the medical literature to date. We report the case of a 38-year-old Caucasian female with refractory acute myeloid leukaemia who developed painless bilateral blurred vision within 2 weeks of commencing a course of IFN alpha-2a. Extensive clinical workup demonstrated bilateral retrobulbar optic neuropathy. We report the clinical evaluation of this first documented case and discuss the possible aetiologies of her presentation.
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