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    Symptomatic therapy and rehabilitation in primary progressive multiple sclerosis.

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    17
    Author
    Khan, F; Amatya, B; Turner-Stokes, L
    Date
    2011
    Source Title
    Neurology Research International
    Publisher
    Hindawi Limited
    University of Melbourne Author/s
    Khan, Farees; Amatya, Bhasker; Bhasker, Amatya
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Khan, F., Amatya, B. & Turner-Stokes, L. (2011). Symptomatic therapy and rehabilitation in primary progressive multiple sclerosis.. Neurol Res Int, 2011, pp.740505-. https://doi.org/10.1155/2011/740505.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260109
    DOI
    10.1155/2011/740505
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196037
    Abstract
    Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults. Primary progressive MS (PPMS) constitutes about 10% of cases, and is characterized by a steady decline in function with no acute attacks. The rate of deterioration from disease onset is more rapid than relapsing remitting and secondary progressive MS types. Multiple system involvement at onset and rapid early progression have a worse prognosis. PPMS can cause significant disability and impact on quality of life. Recent studies are biased in favour of relapsing remitting patients as treatment is now available for them and they are more likely to be seen at MS clinics. Since prognosis for PPMS is worse than other types of MS, the focus of rehabilitation is on managing disability and enhancing participation, and application of a "neuropalliative" approach as the disease progresses. This chapter presents the symptomatic treatment and rehabilitation for persons with MS, including PPMS. A multidisciplinary approach optimizes the intermediate and long-term medical, psychological and social outcomes in this population. Restoration and maintenance of functional independence and societal reintegration, and issues relating to quality of life are addressed in rehabilitation processes.

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