Transcriptional Analysis of T Cells Resident in Human Skin
Web of Science
AuthorLi, J; Olshansky, M; Carbone, FR; Ma, JZ
Source TitlePLoS One
PublisherPUBLIC LIBRARY SCIENCE
AffiliationBiochemistry and Molecular Biology
Microbiology and Immunology
Document TypeJournal Article
CitationsLi, J., Olshansky, M., Carbone, F. R. & Ma, J. Z. (2016). Transcriptional Analysis of T Cells Resident in Human Skin. PLOS ONE, 11 (1), https://doi.org/10.1371/journal.pone.0148351.
Access StatusOpen Access
Human skin contains various populations of memory T cells in permanent residence and in transit. Arguably, the best characterized of the skin subsets are the CD8(+) permanently resident memory T cells (TRM) expressing the integrin subunit, CD103. In order to investigate the remaining skin T cells, we isolated skin-tropic (CLA(+)) helper T cells, regulatory T cells, and CD8(+) CD103(-) T cells from skin and blood for RNA microarray analysis to compare the transcriptional profiles of these groups. We found that despite their common tropism, the T cells isolated from skin were transcriptionally distinct from blood-derived CLA(+) T cells. A shared pool of genes contributed to the skin/blood discrepancy, with substantial overlap in differentially expressed genes between each T cell subset. Gene set enrichment analysis further showed that the differential gene profiles of each human skin T cell subset were significantly enriched for previously identified TRM core signature genes. Our results support the hypothesis that human skin may contain additional TRM or TRM-like populations.
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