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dc.contributor.authorLi, J
dc.contributor.authorOlshansky, M
dc.contributor.authorCarbone, FR
dc.contributor.authorMa, JZ
dc.date.accessioned2021-02-05T00:45:31Z
dc.date.available2021-02-05T00:45:31Z
dc.date.issued2016-01-29
dc.identifierpii: PONE-D-15-53819
dc.identifier.citationLi, J., Olshansky, M., Carbone, F. R. & Ma, J. Z. (2016). Transcriptional Analysis of T Cells Resident in Human Skin. PLOS ONE, 11 (1), https://doi.org/10.1371/journal.pone.0148351.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/260137
dc.description.abstractHuman skin contains various populations of memory T cells in permanent residence and in transit. Arguably, the best characterized of the skin subsets are the CD8(+) permanently resident memory T cells (TRM) expressing the integrin subunit, CD103. In order to investigate the remaining skin T cells, we isolated skin-tropic (CLA(+)) helper T cells, regulatory T cells, and CD8(+) CD103(-) T cells from skin and blood for RNA microarray analysis to compare the transcriptional profiles of these groups. We found that despite their common tropism, the T cells isolated from skin were transcriptionally distinct from blood-derived CLA(+) T cells. A shared pool of genes contributed to the skin/blood discrepancy, with substantial overlap in differentially expressed genes between each T cell subset. Gene set enrichment analysis further showed that the differential gene profiles of each human skin T cell subset were significantly enriched for previously identified TRM core signature genes. Our results support the hypothesis that human skin may contain additional TRM or TRM-like populations.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.titleTranscriptional Analysis of T Cells Resident in Human Skin
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0148351
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS One
melbourne.source.volume11
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1035640
melbourne.contributor.authorOlshansky, Moshe
melbourne.contributor.authorCarbone, Francis
melbourne.contributor.authorMa, Joel
melbourne.contributor.authorLi, Jane Jie
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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