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dc.contributor.authorLin, MY
dc.contributor.authorKondalsamy-Chennakesavan, S
dc.contributor.authorBernshaw, D
dc.contributor.authorKhaw, P
dc.contributor.authorNarayan, K
dc.date.accessioned2021-02-05T00:46:28Z
dc.date.available2021-02-05T00:46:28Z
dc.date.issued2016-11-01
dc.identifierpii: 27.e59
dc.identifier.citationLin, M. Y., Kondalsamy-Chennakesavan, S., Bernshaw, D., Khaw, P. & Narayan, K. (2016). Carcinoma of the cervix in elderly patients treated with radiotherapy: patterns of care and treatment outcomes. JOURNAL OF GYNECOLOGIC ONCOLOGY, 27 (6), https://doi.org/10.3802/jgo.2016.27.e59.
dc.identifier.issn2005-0380
dc.identifier.urihttp://hdl.handle.net/11343/260144
dc.description.abstractOBJECTIVE: The aim of this analysis was to examine the management of cervix cancer in elderly patients referred for radiotherapy and the results of treatment in terms of overall survival (OS), relapse-free survival (RFS), and treatment-related toxicities. METHODS: Patients were eligible if they were aged ≥75 years, newly diagnosed with cervix cancer and referred for radiotherapy as part of their treatment. Patient details were retrieved from the gynaecology service database where clinical, histopathological treatment and follow-up data were prospectively collected. RESULTS: From 1998 to 2010, 126 patients aged ≥75 years, met selection criteria. Median age was 81.5 years. Eighty-one patients had definitive radiotherapy, 10 received adjuvant radiotherapy and 35 had palliative radiotherapy. Seventy-one percent of patients had the International Federation of Gynecology and Obstetrics stage 1b-2b disease. Median follow-up was 37 months. OS and RFS at 3 years among those treated with curative intent were 66.6% and 75.9% respectively with majority of patients dying without any evidence of cervix cancer. Grade 2 or more late toxicities were: bladder 5%, bowel 11%, and vagina 27%. Eastern Cooperative Oncology Group (ECOG) status was a significant predictor of OS and RFS with each unit increment in ECOG score increased the risk of death by 1.69 times (p<0.001). CONCLUSION: Following appropriate patient selection, elderly patients treated curatively with radiotherapy for cervix cancer have good disease control. Palliative hypofractionated regimens are well tolerated in patients unsuitable for radical treatment.
dc.languageEnglish
dc.publisherKOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleCarcinoma of the cervix in elderly patients treated with radiotherapy: patterns of care and treatment outcomes
dc.typeJournal Article
dc.identifier.doi10.3802/jgo.2016.27.e59
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of gynecologic oncology
melbourne.source.volume27
melbourne.source.issue6
dc.rights.licenseCC BY-NC
melbourne.elementsid1093950
melbourne.contributor.authorNarayan, Kailash
melbourne.contributor.authorBernshaw, David
dc.identifier.eissn2005-0399
melbourne.accessrightsOpen Access


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