University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high grade cervical intraepithelial neoplasia after definitive surgical therapy: Post-hoc analysis from a randomized controlled trial

    Thumbnail
    Download
    Published version (1.358Mb)

    Citations
    Scopus
    Altmetric
    47
    Author
    Garland, SM; Paavonen, J; Jaisamrarn, U; Naud, P; Salmeron, J; Chow, S-N; Apter, D; Castellsague, X; Teixeira, JC; Skinner, SR; ...
    Date
    2016-12-01
    Source Title
    International Journal of Cancer
    Publisher
    WILEY
    University of Melbourne Author/s
    Wark, Suzanne
    Affiliation
    Obstetrics and Gynaecology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Garland, S. M., Paavonen, J., Jaisamrarn, U., Naud, P., Salmeron, J., Chow, S. -N., Apter, D., Castellsague, X., Teixeira, J. C., Skinner, S. R., Hedrick, J., Limson, G., Schwarz, T. F., Poppe, W. A. J., Xavier Bosch, F., de Carvalho, N. S., Germar, M. J. V., Peters, K., Rowena Del Rosario-Raymundo, M. ,... Dubin, G. (2016). Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high grade cervical intraepithelial neoplasia after definitive surgical therapy: Post-hoc analysis from a randomized controlled trial. INTERNATIONAL JOURNAL OF CANCER, 139 (12), pp.2812-2826. https://doi.org/10.1002/ijc.30391.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260159
    DOI
    10.1002/ijc.30391
    Abstract
    We evaluated the efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in preventing HPV-related disease after surgery for cervical lesions in a post-hoc analysis of the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681). Healthy women aged 15-25 years were randomized (1:1) to receive vaccine or control at months 0, 1 and 6 and followed for 4 years. Women were enrolled regardless of their baseline HPV DNA status, HPV-16/18 serostatus, or cytology, but excluded if they had previous or planned colposcopy. The primary and secondary endpoints of PATRICIA have been reported previously; the present post-hoc analysis evaluated efficacy in a subset of women who underwent an excisional procedure for cervical lesions after vaccination. The main outcome was the incidence of subsequent HPV-related cervical intraepithelial neoplasia grade 2 or greater (CIN2+) 60 days or more post-surgery. Other outcomes included the incidence of HPV-related CIN1+, and vulvar or vaginal intraepithelial neoplasia (VIN/VaIN) 60 days or more post-surgery. Of the total vaccinated cohort of 18,644 women (vaccine = 9,319; control = 9,325), 454 (vaccine = 190, control = 264) underwent an excisional procedure during the trial. Efficacy 60 days or more post-surgery for a first lesion, irrespective of HPV DNA results, was 88.2% (95% CI: 14.8, 99.7) against CIN2+ and 42.6% (-21.1, 74.1) against CIN1+. No VIN was reported and one woman in each group had VaIN2+ 60 days or more post-surgery. Women who undergo surgical therapy for cervical lesions after vaccination with the HPV-16/18 vaccine may continue to benefit from vaccination, with a reduced risk of developing subsequent CIN2+.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52609]
    • Obstetrics and Gynaecology - Research Publications [828]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors