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dc.contributor.authorWoon, HG
dc.contributor.authorBraun, A
dc.contributor.authorLi, J
dc.contributor.authorSmith, C
dc.contributor.authorEdwards, J
dc.contributor.authorSierro, F
dc.contributor.authorFeng, CG
dc.contributor.authorKhanna, R
dc.contributor.authorElliot, M
dc.contributor.authorBell, A
dc.contributor.authorHislop, AD
dc.contributor.authorTangye, SG
dc.contributor.authorRickinson, AB
dc.contributor.authorGebhardt, T
dc.contributor.authorBritton, WJ
dc.contributor.authorPalendira, U
dc.date.accessioned2021-02-05T00:48:41Z
dc.date.available2021-02-05T00:48:41Z
dc.date.issued2016-08-01
dc.identifierpii: PPATHOGENS-D-16-00499
dc.identifier.citationWoon, H. G., Braun, A., Li, J., Smith, C., Edwards, J., Sierro, F., Feng, C. G., Khanna, R., Elliot, M., Bell, A., Hislop, A. D., Tangye, S. G., Rickinson, A. B., Gebhardt, T., Britton, W. J. & Palendira, U. (2016). Compartmentalization of Total and VirusSpecific Tissue-Resident Memory CD8+T Cells in Human Lymphoid Organs. PLOS PATHOGENS, 12 (8), https://doi.org/10.1371/journal.ppat.1005799.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/260160
dc.description.abstractDisruption of T cell memory during severe immune suppression results in reactivation of chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How different subsets of memory T cells contribute to the protective immunity against these viruses remains poorly defined. In this study we examined the compartmentalization of virus-specific, tissue resident memory CD8+ T cells in human lymphoid organs. This revealed two distinct populations of memory CD8+ T cells, that were CD69+CD103+ and CD69+CD103-, and were retained within the spleen and tonsils in the absence of recent T cell stimulation. These two types of memory cells were distinct not only in their phenotype and transcriptional profile, but also in their anatomical localization within tonsils and spleen. The EBV-specific, but not CMV-specific, CD8+ memory T cells preferentially accumulated in the tonsils and acquired a phenotype that ensured their retention at the epithelial sites where EBV replicates. In vitro studies revealed that the cytokine IL-15 can potentiate the retention of circulating effector memory CD8+ T cells by down-regulating the expression of sphingosine-1-phosphate receptor, required for T cell exit from tissues, and its transcriptional activator, Kruppel-like factor 2 (KLF2). Within the tonsils the expression of IL-15 was detected in regions where CD8+ T cells localized, further supporting a role for this cytokine in T cell retention. Together this study provides evidence for the compartmentalization of distinct types of resident memory T cells that could contribute to the long-term protection against persisting viral infections.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCompartmentalization of Total and VirusSpecific Tissue-Resident Memory CD8+T Cells in Human Lymphoid Organs
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1005799
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS Pathogens
melbourne.source.volume12
melbourne.source.issue8
dc.rights.licenseCC BY
melbourne.elementsid1094452
melbourne.contributor.authorGebhardt, Thomas
melbourne.contributor.authorBraun, Asolina
melbourne.contributor.authorLi, Jane Jie
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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