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dc.contributor.authorNagel, R
dc.contributor.authorTraub, RJ
dc.contributor.authorAllcock, RJN
dc.contributor.authorKwan, MMS
dc.contributor.authorBielefeldt-Ohmann, H
dc.date.accessioned2021-02-05T00:49:07Z
dc.date.available2021-02-05T00:49:07Z
dc.date.issued2016-08-31
dc.identifierpii: 10.1186/s40168-016-0191-0
dc.identifier.citationNagel, R., Traub, R. J., Allcock, R. J. N., Kwan, M. M. S. & Bielefeldt-Ohmann, H. (2016). Comparison of faecal microbiota in Blastocystis-positive and Blastocystis-negative irritable bowel syndrome patients. MICROBIOME, 4 (1), https://doi.org/10.1186/s40168-016-0191-0.
dc.identifier.issn2049-2618
dc.identifier.urihttp://hdl.handle.net/11343/260163
dc.description.abstractBACKGROUND: We investigated whether the carriage of Blastocystis in IBS patients was associated with differences in the faecal microbiota. Forty patients with diarrhoea-predominant IBS (26 Blastocystis-positive and 14 Blastocystis-negative) and 57 healthy controls (HC) (42 Blastocystis-positive and 15 Blastocystis-negative) submitted faecal samples for metataxonomic analysis of the 16S ribosomal RNA gene. Differences in the relative abundance of bacteria in these IBS and HC groups were evaluated from phylum to genus level. RESULTS: Significant changes were observed in two dominant phyla in IBS patients, regardless of Blastocystis infection status, namely a rise in Firmicutes and a statistically significant reduction in relative abundance of Bacteroidetes (with a threefold increase in the Firmicutes to Bacteoridetes ratio). Significant differences at genus level in IBS subjects compared to HC were also observed for many bacterial species. However, further clinical subgroup analysis of Blastocystis-positive and Blastocystis-negative subjects, regardless of symptoms, showed no significant differences at the phylum or genus level in IBS-P compared to IBS-N. CONCLUSIONS: Significant differences in the faecal microbiota between diarrhoea-predominant IBS patients and healthy controls were confirmed, but the carriage of Blastocystis did not significantly alter the faecal microbiota. If Blastocystis-positive patients represent a separate clinical subtype of IBS, this group is not identified by changes in the microbiota.
dc.languageEnglish
dc.publisherBIOMED CENTRAL LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleComparison of faecal microbiota in Blastocystis-positive and Blastocystis-negative irritable bowel syndrome patients
dc.typeJournal Article
dc.identifier.doi10.1186/s40168-016-0191-0
melbourne.affiliation.departmentVeterinary Biosciences
melbourne.affiliation.facultyVeterinary and Agricultural Sciences
melbourne.source.titleMicrobiome
melbourne.source.volume4
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1094664
melbourne.contributor.authorTraub, Rebecca
dc.identifier.eissn2049-2618
melbourne.accessrightsOpen Access


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