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dc.contributor.authorDimasuay, KG
dc.contributor.authorBoeuf, P
dc.contributor.authorPowell, TL
dc.contributor.authorJansson, T
dc.date.accessioned2021-02-05T00:52:56Z
dc.date.available2021-02-05T00:52:56Z
dc.date.issued2016-01-29
dc.identifier.citationDimasuay, K. G., Boeuf, P., Powell, T. L. & Jansson, T. (2016). Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. FRONTIERS IN PHYSIOLOGY, 7 (JAN), https://doi.org/10.3389/fphys.2016.00012.
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/11343/260190
dc.description.abstractPlacental responses to maternal perturbations are complex and remain poorly understood. Altered maternal environment during pregnancy such as hypoxia, stress, obesity, diabetes, toxins, altered nutrition, inflammation, and reduced utero-placental blood flow may influence fetal development, which can predispose to diseases later in life. The placenta being a metabolically active tissue responds to these perturbations by regulating the fetal supply of nutrients and oxygen and secretion of hormones into the maternal and fetal circulation. We have proposed that placental nutrient sensing integrates maternal and fetal nutritional cues with information from intrinsic nutrient sensing signaling pathways to balance fetal demand with the ability of the mother to support pregnancy by regulating maternal physiology, placental growth, and placental nutrient transport. Emerging evidence suggests that the nutrient-sensing signaling pathway mechanistic target of rapamycin (mTOR) plays a central role in this process. Thus, placental nutrient sensing plays a critical role in modulating maternal-fetal resource allocation, thereby affecting fetal growth and the life-long health of the fetus.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlePlacental Responses to Changes in the Maternal Environment Determine Fetal Growth
dc.typeJournal Article
dc.identifier.doi10.3389/fphys.2016.00012
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Physiology
melbourne.source.volume7
melbourne.source.issueJAN
dc.rights.licenseCC BY
melbourne.elementsid1037437
melbourne.contributor.authorBoeuf, Philippe
melbourne.contributor.authorDimasuay, Kris
dc.identifier.eissn1664-042X
melbourne.accessrightsOpen Access


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