University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (RMH)
  • Surgery (RMH) - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (RMH)
  • Surgery (RMH) - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Impact of Diabetes Status and Medication on Presentation, Treatment, and Outcome of Stage II Colon Cancer Patients

    Thumbnail
    Download
    Published version (928.7Kb)

    Citations
    Scopus
    Altmetric
    12
    Author
    Bae, S; Wong, H-L; Tie, J; Desai, J; Field, K; Kosmider, S; Fourlanos, S; Jones, I; Skinner, I; Gibbs, P
    Date
    2015-01-01
    Source Title
    Journal of Cancer Epidemiology
    Publisher
    HINDAWI LTD
    University of Melbourne Author/s
    Jones, Ian; Gibbs, Peter; Desai, Jayesh; Fourlanos, Spiros; Skinner, Iain; Tie, Jeanne; Field, Kathryn
    Affiliation
    Surgery (RMH)
    Sir Peter MacCallum Department of Oncology
    Medical Biology (W.E.H.I.)
    Medical Education
    Surgery (Western Health)
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Bae, S., Wong, H. -L., Tie, J., Desai, J., Field, K., Kosmider, S., Fourlanos, S., Jones, I., Skinner, I. & Gibbs, P. (2015). Impact of Diabetes Status and Medication on Presentation, Treatment, and Outcome of Stage II Colon Cancer Patients. JOURNAL OF CANCER EPIDEMIOLOGY, 2015, https://doi.org/10.1155/2015/189132.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260195
    DOI
    10.1155/2015/189132
    Abstract
    Diabetes is a risk factor for colorectal cancer and several reports suggest worse cancer-specific outcomes in diabetes patients. Recent studies in multiple tumour types indicate metformin may positively impact on cancer-specific and overall survival. A population-based series of stage II colorectal cancer patients treated and followed from 2000 to 2013 were analysed for baseline characteristics, treatment, and outcomes. 1116 patients with stage II colon cancer were identified, 55.5% were male and median age was 70.9 years (range 20.5-101.2). The diabetes patients (21.6%, n = 241) were older than nondiabetes patients (median 74.0 versus 69.6, p = 0.0001). There was no impact of diabetes on cancer presentation or pathology. Diabetes patients were less likely to receive adjuvant treatment (13.7 versus 24.8%, p = 0.002) but were equally likely to complete treatment (69.7 versus 67.7%, p = 1.00). Diabetes did not significantly impact cancer recurrence (HR = 1.07, 95% CI 0.71-1.63) or overall survival (HR = 1.23, 95% CI 0.88-1.72), adjusted for age. Diabetes medication did not impact cancer recurrence or survival. Cancer presentation and outcomes in diabetes patients are comparable to those of nondiabetes patients in those with stage II colon cancer. The effect of metformin merits further evaluation in patients with colon cancer.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52369]
    • Medicine and Radiology - Research Publications [3309]
    • Surgery (Western Health) - Research Publications [9]
    • Medical Education - Research Publications [594]
    • Medical Biology - Research Publications [1412]
    • Sir Peter MacCallum Department of Oncology - Research Publications [1029]
    • Surgery (RMH) - Research Publications [347]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors