Assessment of antigenic difference of equine influenza virus strains by challenge study in horses.
AuthorYamanaka, T; Nemoto, M; Bannai, H; Tsujimura, K; Kondo, T; Matsumura, T; Gildea, S; Cullinane, A
Source TitleInfluenza and Other Respiratory Viruses
University of Melbourne Author/sBannai, Hiroshi
Document TypeJournal Article
CitationsYamanaka, T., Nemoto, M., Bannai, H., Tsujimura, K., Kondo, T., Matsumura, T., Gildea, S. & Cullinane, A. (2016). Assessment of antigenic difference of equine influenza virus strains by challenge study in horses.. Influenza Other Respir Viruses, 10 (6), pp.536-539. https://doi.org/10.1111/irv.12418.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059955
We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 (LP93) exhibited reduced cross-neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 (CL11). As a result, Japanese vaccine manufacturers will replace LP93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP93 were challenged by exposure to a nebulized aerosol of CL11. The durations of pyrexia (≥38.5°C) and other adverse clinical symptoms experienced by the Y10 group were significantly shorter than those of the LP93 group.
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