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dc.contributor.authorDi Rosa, F
dc.contributor.authorGebhardt, T
dc.date.accessioned2021-02-05T00:59:08Z
dc.date.available2021-02-05T00:59:08Z
dc.date.issued2016-02-16
dc.identifier.citationDi Rosa, F. & Gebhardt, T. (2016). Bone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells. FRONTIERS IN IMMUNOLOGY, 7 (FEB), https://doi.org/10.3389/fimmu.2016.00051.
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11343/260230
dc.description.abstractChanges in T cell trafficking accompany the naive to memory T cell antigen-driven differentiation, which remains an incompletely defined developmental step. Upon priming, each naive T cell encounters essential signals - i.e., antigen, co-stimuli and cytokines - in a secondary lymphoid organ; nevertheless, its daughter effector and memory T cells recirculate and receive further signals during their migration through various lymphoid and non-lymphoid organs. These additional signals from tissue microenvironments have an impact on immune response features, including T cell effector function, expansion and contraction, memory differentiation, long-term maintenance, and recruitment upon antigenic rechallenge into local and/or systemic responses. The critical role of T cell trafficking in providing efficient T cell memory has long been a focus of interest. It is now well recognized that naive and memory T cells have different migratory pathways, and that memory T cells are heterogeneous with respect to their trafficking. We and others have observed that, long time after priming, memory T cells are preferentially found in certain niches such as the bone marrow (BM) or at the skin/mucosal site of pathogen entry, even in the absence of residual antigen. The different underlying mechanisms and peculiarities of resulting immunity are currently under study. In this review, we summarize key findings on BM and tissue-resident memory (TRM) T cells and revisit some issues in memory T cell maintenance within such niches. Moreover, we discuss BM seeding by memory T cells in the context of migration patterns and protective functions of either recirculating or TRM T cells.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleBone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells
dc.typeJournal Article
dc.identifier.doi10.3389/fimmu.2016.00051
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Immunology
melbourne.source.volume7
melbourne.source.issueFEB
dc.rights.licenseCC BY
melbourne.elementsid1041663
melbourne.contributor.authorGebhardt, Thomas
dc.identifier.eissn1664-3224
melbourne.accessrightsOpen Access


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