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dc.contributor.authorBergouignan, A
dc.contributor.authorLatouche, C
dc.contributor.authorHeywood, S
dc.contributor.authorGrace, MS
dc.contributor.authorReddy-Luthmoodoo, M
dc.contributor.authorNatoli, AK
dc.contributor.authorOwen, N
dc.contributor.authorDunstan, DW
dc.contributor.authorKingwell, BA
dc.date.accessioned2021-02-05T01:00:43Z
dc.date.available2021-02-05T01:00:43Z
dc.date.issued2016-08-24
dc.identifierpii: srep32044
dc.identifier.citationBergouignan, A., Latouche, C., Heywood, S., Grace, M. S., Reddy-Luthmoodoo, M., Natoli, A. K., Owen, N., Dunstan, D. W. & Kingwell, B. A. (2016). Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep32044.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/260239
dc.description.abstractEpidemiological studies have observed associations between frequent interruptions of sitting time with physical activity bouts and beneficial metabolic outcomes, even in individuals who regularly exercise. Frequent interruptions to prolonged sitting reduce postprandial plasma glucose. Here we studied potential skeletal muscle mechanisms accounting for this improved control of glycemia in overweight adults under conditions of one day uninterrupted sitting and sitting interrupted with light-intensity or moderate-intensity walking every 20-min (n = 8); and, after three days of either uninterrupted sitting or light-intensity walking interruptions (n = 5). Contraction- and insulin-mediated glucose uptake signaling pathways as well as changes in oxidative phosphorylation proteins were examined. We showed that 1) both interventions reduce postprandial glucose concentration, 2) acute interruptions to sitting over one day stimulate the contraction-mediated glucose uptake pathway, 3) both acute interruptions to sitting with moderate-intensity activity over one day and light-intensity activity over three days induce a transition to modulation of the insulin-signaling pathway, in association with increased capacity for glucose transport. Only the moderate-intensity interruptions resulted in greater capacity for glycogen synthesis and likely for ATP production. These observations contribute to a mechanistic explanation of improved postprandial glucose metabolism with regular interruptions to sitting time, a promising preventive strategy for metabolic diseases.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleFrequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials
dc.typeJournal Article
dc.identifier.doi10.1038/srep32044
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1095724
melbourne.contributor.authorLee, Alaina
melbourne.contributor.authorOWEN, NEVILLE
melbourne.contributor.authorKingwell, Bronwyn
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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