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dc.contributor.authorSouilhol, C
dc.contributor.authorGonneau, C
dc.contributor.authorLendinez, JG
dc.contributor.authorBatsivari, A
dc.contributor.authorRybtsov, S
dc.contributor.authorWilson, H
dc.contributor.authorMorgado-Palacin, L
dc.contributor.authorHills, D
dc.contributor.authorTaoudi, S
dc.contributor.authorAntonchuk, J
dc.contributor.authorZhao, S
dc.contributor.authorMedvinsky, A
dc.date.accessioned2021-02-05T01:03:21Z
dc.date.available2021-02-05T01:03:21Z
dc.date.issued2016-03-01
dc.identifierpii: ncomms10784
dc.identifier.citationSouilhol, C., Gonneau, C., Lendinez, J. G., Batsivari, A., Rybtsov, S., Wilson, H., Morgado-Palacin, L., Hills, D., Taoudi, S., Antonchuk, J., Zhao, S. & Medvinsky, A. (2016). Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms10784.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/260254
dc.description.abstractDuring embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially in the ventral domain of the aorta in the aorta-gonad-mesonephros (AGM) region. Several signalling pathways such as Notch, Wnt, Shh and RA are implicated in this process, yet how these interact to regulate the emergence of HSCs has not previously been described in mammals. Using a combination of ex vivo and in vivo approaches, we report here that stage-specific reciprocal dorso-ventral inductive interactions and lateral input from the urogenital ridges are required to drive HSC development in the aorta. Our study strongly suggests that these inductive interactions in the AGM region are mediated by the interplay between spatially polarized signalling pathways. Specifically, Shh produced in the dorsal region of the AGM, stem cell factor in the ventral and lateral regions, and BMP inhibitory signals in the ventral tissue are integral parts of the regulatory system involved in the development of HSCs.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms10784
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1042267
melbourne.contributor.authorTaoudi, Samir
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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