The Significance of a Common idiotype (1F7) on Antibodies against Human immune Deficiency virus Type 1 and Hepatitis C virus
AuthorMuller, S; Parsons, MS; Kohler, H; Grant, M
Source TitleFrontiers in Oncology
PublisherFRONTIERS MEDIA SA
University of Melbourne Author/sParsons, Matt
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsMuller, S., Parsons, M. S., Kohler, H. & Grant, M. (2016). The Significance of a Common idiotype (1F7) on Antibodies against Human immune Deficiency virus Type 1 and Hepatitis C virus. FRONTIERS IN ONCOLOGY, 6 (FEB), https://doi.org/10.3389/fonc.2016.00011.
Access StatusOpen Access
In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies expressing the idiotype defined by 1F7 are dominant in HIV-1 infection and are also found on many broadly neutralizing antibodies against HIV-1. This regulatory idiotypic axis offers opportunities for exploitation in vaccine development for HIV-1, HCV, and other chronic viral infections.
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