University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne School of Population and Global Health
  • Melbourne School of Population and Global Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne School of Population and Global Health
  • Melbourne School of Population and Global Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders

    Thumbnail
    Download
    Published version (99.63Kb)

    Citations
    Scopus
    Altmetric
    12
    Author
    Kristjansson, S; McCutcheon, VV; Agrawal, A; Lynskey, MT; Conroy, E; Statham, DJ; Madden, PAF; Henders, AK; Todorov, AA; Bucholz, KK; ...
    Date
    2016-02-01
    Source Title
    Brain and Behavior
    Publisher
    JOHN WILEY & SONS INC
    University of Melbourne Author/s
    Degenhardt, Louisa
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Kristjansson, S., McCutcheon, V. V., Agrawal, A., Lynskey, M. T., Conroy, E., Statham, D. J., Madden, P. A. F., Henders, A. K., Todorov, A. A., Bucholz, K. K., Degenhardt, L., Martin, N. G., Heath, A. C. & Nelson, E. C. (2016). The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders. BRAIN AND BEHAVIOR, 6 (2), https://doi.org/10.1002/brb3.432.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260258
    DOI
    10.1002/brb3.432
    Abstract
    INTRODUCTION: Forms of childhood trauma tend to co-occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations. METHODS: We performed multigroup confirmatory factor analysis (CFA), separately by sex, using data from the Childhood Trauma (CT) Study's sample of twins and siblings (N = 2594) to derive three first-order factors (childhood physical abuse, childhood sexual abuse, and parental partner abuse) and, as hypothesized, one higher order, childhood trauma factor (CTF) representing a measure of their common variance. RESULTS: CFA produced a good-fitting model in the CT Study; we replicated the model in the Comorbidity and Trauma (CAT) Study's sample (N = 1981) of opioid-dependent cases and controls. In both samples, first-order factors are moderately correlated (indicating they measure largely unique, but related constructs) and their loadings on the CTF suggest it provides a reasonable measure of their common variance. We examined the association of CTF score with risk for psychiatric and substance use disorders in these samples and the OZ-ALC GWAS sample (N = 1538) in which CT Study factor loadings were applied. We found that CTF scores are strongly associated with liability for psychiatric and substance use disorders in all three samples; estimates of risk are extremely consistent across samples. CONCLUSIONS: The CTF is a continuous, robust measure that captures the common variance across forms of childhood trauma and provides a means to estimate shared liability while avoiding multicollinearity.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52369]
    • Melbourne School of Population and Global Health - Research Publications [5312]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors