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dc.contributor.authorMartin, TJ
dc.date.accessioned2021-02-05T01:10:29Z
dc.date.available2021-02-05T01:10:29Z
dc.date.issued2014-02
dc.identifier.citationMartin, T. J. (2014). Bone biology and anabolic therapies for bone: current status and future prospects.. J Bone Metab, 21 (1), pp.8-20. https://doi.org/10.11005/jbm.2014.21.1.8.
dc.identifier.issn2287-6375
dc.identifier.urihttp://hdl.handle.net/11343/260294
dc.description.abstractBone is continuously remodelled at many sites asynchronously throughout the skeleton, with bone formation and resorption balanced at these sites to retain bone structure. Negative balance resulting in bone loss and osteoporosis, with consequent fractures, has mainly been prevented or treated by anti-resorptive drugs that inhibit osteoclast formation and/or activity, with new prospects now of anabolic treatments that restore bone that has been lost. The anabolic effectiveness of parathyroid hormone has been established, and an exciting new prospect is presented of neutralising antibody against the osteocyte protein, sclerostin. The cellular actions of these two anabolic treatments differ, and the mechanisms will need to be kept in mind in devising their best use. On present evidence it seems likely that treatment with either of these anabolic agents will need to be followed by anti-resorptive treatment in order to maintain bone that has been restored. No matter how effective anabolic therapies for the skeleton become, it seems highly likely that there will be a continuing need for safe, effective anti-resorptive drugs.
dc.languageeng
dc.publisherThe Korean Society of Bone Metabolism (KAMJE)
dc.titleBone biology and anabolic therapies for bone: current status and future prospects.
dc.typeJournal Article
dc.identifier.doi10.11005/jbm.2014.21.1.8
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of bone metabolism
melbourne.source.volume21
melbourne.source.issue1
melbourne.source.pages8-20
dc.rights.licenseCC BY-NC
melbourne.elementsid1050587
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970295
melbourne.contributor.authorMartin, Thomas
dc.identifier.eissn2287-7029
melbourne.accessrightsOpen Access


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