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dc.contributor.authorFerrón, SR
dc.contributor.authorRadford, EJ
dc.contributor.authorDomingo-Muelas, A
dc.contributor.authorKleine, I
dc.contributor.authorRamme, A
dc.contributor.authorGray, D
dc.contributor.authorSandovici, I
dc.contributor.authorConstancia, M
dc.contributor.authorWard, A
dc.contributor.authorMenheniott, TR
dc.contributor.authorFerguson-Smith, AC
dc.date.accessioned2021-02-05T01:10:37Z
dc.date.available2021-02-05T01:10:37Z
dc.date.issued2015-09-15
dc.identifierpii: ncomms9265
dc.identifier.citationFerrón, S. R., Radford, E. J., Domingo-Muelas, A., Kleine, I., Ramme, A., Gray, D., Sandovici, I., Constancia, M., Ward, A., Menheniott, T. R. & Ferguson-Smith, A. C. (2015). Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis.. Nat Commun, 6 (1), pp.8265-. https://doi.org/10.1038/ncomms9265.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/260295
dc.description.abstractGenomic imprinting is implicated in the control of gene dosage in neurogenic niches. Here we address the importance of Igf2 imprinting for murine adult neurogenesis in the subventricular zone (SVZ) and in the subgranular zone (SGZ) of the hippocampus in vivo. In the SVZ, paracrine IGF2 is a cerebrospinal fluid and endothelial-derived neurogenic factor requiring biallelic expression, with mutants having reduced activation of the stem cell pool and impaired olfactory bulb neurogenesis. In contrast, Igf2 is imprinted in the hippocampus acting as an autocrine factor expressed in neural stem cells (NSCs) solely from the paternal allele. Conditional mutagenesis of Igf2 in blood vessels confirms that endothelial-derived IGF2 contributes to NSC maintenance in SVZ but not in the SGZ, and that this is regulated by the biallelic expression of IGF2 in the vascular compartment. Our findings indicate that a regulatory decision to imprint or not is a functionally important mechanism of transcriptional dosage control in adult neurogenesis.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.titleDifferential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis.
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms9265
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.facultyCollected Works
melbourne.source.titleNature Communications
melbourne.source.volume6
melbourne.source.issue1
melbourne.source.pages8265-
dc.rights.licenseCC BY
melbourne.elementsid1050734
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579569
melbourne.contributor.authorMenheniott, Trevelyan
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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