Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers

Download
Author
Allaoui, R; Bergenfelz, C; Mohlin, S; Hagerling, C; Salari, K; Werb, Z; Anderson, RL; Ethier, SP; Jirstrom, K; Pahlman, S; ...Date
2016-10-11Source Title
Nature CommunicationsPublisher
NATURE PUBLISHING GROUPUniversity of Melbourne Author/s
Anderson, RobinAffiliation
Sir Peter MacCallum Department of OncologyMetadata
Show full item recordDocument Type
Journal ArticleCitations
Allaoui, R., Bergenfelz, C., Mohlin, S., Hagerling, C., Salari, K., Werb, Z., Anderson, R. L., Ethier, S. P., Jirstrom, K., Pahlman, S., Bexell, D., Tahin, B., Johansson, M. E., Larsson, C. & Leandersson, K. (2016). Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms13050.Access Status
Open AccessAbstract
Triple-negative (TN) breast cancers (ER-PR-HER2-) are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory cells are even more aggressive. The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown. Here, we show that primary human monocytes have a survival advantage, proliferate in vivo and develop into immunosuppressive myeloid cells expressing the myeloid-derived suppressor cell marker S100A9 only in a TN breast cancer environment. This results in activation of cancer-associated fibroblasts and expression of CXCL16, which we show to be a monocyte chemoattractant. We propose that this migratory feedback loop amplifies the formation of a reactive stroma, contributing to the aggressive phenotype of TN breast tumours. These insights could help select more suitable therapies targeting the stromal component of these tumours, and could aid prediction of drug resistance.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References