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dc.contributor.authorAllaoui, R
dc.contributor.authorBergenfelz, C
dc.contributor.authorMohlin, S
dc.contributor.authorHagerling, C
dc.contributor.authorSalari, K
dc.contributor.authorWerb, Z
dc.contributor.authorAnderson, RL
dc.contributor.authorEthier, SP
dc.contributor.authorJirstrom, K
dc.contributor.authorPahlman, S
dc.contributor.authorBexell, D
dc.contributor.authorTahin, B
dc.contributor.authorJohansson, ME
dc.contributor.authorLarsson, C
dc.contributor.authorLeandersson, K
dc.date.accessioned2021-02-05T01:12:41Z
dc.date.available2021-02-05T01:12:41Z
dc.date.issued2016-10-11
dc.identifierpii: ncomms13050
dc.identifier.citationAllaoui, R., Bergenfelz, C., Mohlin, S., Hagerling, C., Salari, K., Werb, Z., Anderson, R. L., Ethier, S. P., Jirstrom, K., Pahlman, S., Bexell, D., Tahin, B., Johansson, M. E., Larsson, C. & Leandersson, K. (2016). Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms13050.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/260309
dc.description.abstractTriple-negative (TN) breast cancers (ER-PR-HER2-) are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory cells are even more aggressive. The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown. Here, we show that primary human monocytes have a survival advantage, proliferate in vivo and develop into immunosuppressive myeloid cells expressing the myeloid-derived suppressor cell marker S100A9 only in a TN breast cancer environment. This results in activation of cancer-associated fibroblasts and expression of CXCL16, which we show to be a monocyte chemoattractant. We propose that this migratory feedback loop amplifies the formation of a reactive stroma, contributing to the aggressive phenotype of TN breast tumours. These insights could help select more suitable therapies targeting the stromal component of these tumours, and could aid prediction of drug resistance.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleCancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms13050
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1103807
melbourne.contributor.authorAnderson, Robin
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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