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    The impact of extended bed rest on the musculoskeletal system in the critical care environment

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    Author
    Parry, SM; Puthucheary, ZA
    Date
    2015-01-01
    Source Title
    Extreme physiology & medicine
    Publisher
    BMC
    University of Melbourne Author/s
    Parry, Selina
    Affiliation
    Medicine Dentistry & Health Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Parry, S. M. & Puthucheary, Z. A. (2015). The impact of extended bed rest on the musculoskeletal system in the critical care environment. EXTREME PHYSIOLOGY & MEDICINE, 4 (1), https://doi.org/10.1186/s13728-015-0036-7.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260329
    DOI
    10.1186/s13728-015-0036-7
    Abstract
    Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density and impairment in other body systems evident within the first week of bed rest which is further exacerbated in individuals with critical illness. Our understanding of the aetiology and secondary consequences of prolonged immobilization in the critically ill is improving with recent and ongoing research to establish the cause, effect, and best treatment options. This review aims to describe the current literature on bed rest models for examining immobilization-induced changes in the musculoskeletal system and pathophysiology of immobilisation in critical illness including examination of intracellular signalling processes involved. Finally, the review examines the current barriers to early activity and mobilization and potential rehabilitation strategies, which are being, investigated which may reverse the effects of prolonged bed rest. Addressing the deleterious effects of immobilization is a major step in treatment and prevention of the public health issue, that is, critical illness survivorship.

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