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dc.contributor.authorBastiani, M
dc.contributor.authorLiu, L
dc.contributor.authorHill, MM
dc.contributor.authorJedrychowski, MP
dc.contributor.authorNixon, SJ
dc.contributor.authorLo, HP
dc.contributor.authorAbankwa, D
dc.contributor.authorLuetterforst, R
dc.contributor.authorFernandez-Rojo, M
dc.contributor.authorBreen, MR
dc.contributor.authorGygi, SP
dc.contributor.authorVinten, J
dc.contributor.authorWalser, PJ
dc.contributor.authorNorth, KN
dc.contributor.authorHancock, JF
dc.contributor.authorPilch, PF
dc.contributor.authorParton, RG
dc.date.accessioned2021-02-05T01:16:19Z
dc.date.available2021-02-05T01:16:19Z
dc.date.issued2009-06-29
dc.identifierpii: jcb.200903053
dc.identifier.citationBastiani, M., Liu, L., Hill, M. M., Jedrychowski, M. P., Nixon, S. J., Lo, H. P., Abankwa, D., Luetterforst, R., Fernandez-Rojo, M., Breen, M. R., Gygi, S. P., Vinten, J., Walser, P. J., North, K. N., Hancock, J. F., Pilch, P. F. & Parton, R. G. (2009). MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. JOURNAL OF CELL BIOLOGY, 185 (7), pp.1259-1273. https://doi.org/10.1083/jcb.200903053.
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/11343/260331
dc.description.abstractPolymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer-based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds to C kinase (SRBC)/Cavin-3, and muscle-restricted coiled-coil protein (MURC)/Cavin-4, forms a multiprotein complex that associates with caveolae. This complex can constitutively assemble in the cytosol and associate with caveolin at plasma membrane caveolae. Cavin-1, but not other cavins, can induce caveola formation in a heterologous system and is required for the recruitment of the cavin complex to caveolae. The tissue-restricted expression of cavins suggests that caveolae may perform tissue-specific functions regulated by the composition of the cavin complex. Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleMURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes
dc.typeJournal Article
dc.identifier.doi10.1083/jcb.200903053
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleThe Journal of Cell Biology
melbourne.source.volume185
melbourne.source.issue7
melbourne.source.pages1259-1273
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1051654
melbourne.contributor.authorNorth, Kathryn
dc.identifier.eissn1540-8140
melbourne.accessrightsOpen Access


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