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    A quantum spin-probe molecular microscope

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    15
    Author
    Perunicic, VS; Hill, CD; Hall, LT; Hollenberg, LCL
    Date
    2016-10-11
    Source Title
    Nature Communications
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Hall, Liam; Hollenberg, Lloyd; Perunicic, Viktor; Hill, Charles
    Affiliation
    School of Physics
    Metadata
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    Document Type
    Journal Article
    Citations
    Perunicic, V. S., Hill, C. D., Hall, L. T. & Hollenberg, L. C. L. (2016). A quantum spin-probe molecular microscope. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms12667.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260355
    DOI
    10.1038/ncomms12667
    ARC Grant code
    ARC/FL130100119
    Abstract
    Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule using a quantum spin probe acting simultaneously as the magnetic resonance sensor and source of magnetic field gradient. Signals corresponding to specific regions of the molecule's nuclear spin density are encoded on the quantum state of the probe, which is used to produce a 3D image of the molecular structure. Quantum simulations of the protocol applied to the rapamycin molecule (C51H79NO13) show that the hydrogen and carbon substructure can be imaged at the angstrom level using current spin-probe technology. With prospects for scaling to large molecules and/or fast dynamic conformation mapping using spin labels, this method provides a realistic pathway for single-molecule microscopy.

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