Cerebrospinal Fluid Real-Time Quaking-Induced Conversion Is a Robust and Reliable Test for Sporadic Creutzfeldt-Jakob Disease: An International Study
AuthorMcGuire, LI; Poleggi, A; Poggiolini, I; Suardi, S; Grznarova, K; Shi, S; de Vil, B; Sarros, S; Satoh, K; Cheng, K; ...
Source TitleAnnals of Neurology
AffiliationMedicine and Radiology
Florey Department of Neuroscience and Mental Health
Document TypeJournal Article
CitationsMcGuire, L. I., Poleggi, A., Poggiolini, I., Suardi, S., Grznarova, K., Shi, S., de Vil, B., Sarros, S., Satoh, K., Cheng, K., Cramm, M., Fairfoul, G., Schmitz, M., Zerr, I., Cras, P., Equestre, M., Tagliavini, F., Atarashi, R., Knox, D. ,... Green, A. (2016). Cerebrospinal Fluid Real-Time Quaking-Induced Conversion Is a Robust and Reliable Test for Sporadic Creutzfeldt-Jakob Disease: An International Study. ANNALS OF NEUROLOGY, 80 (1), pp.160-165. https://doi.org/10.1002/ana.24679.
Access StatusOpen Access
Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice. Ann Neurol 2016;80:160-165.
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