Cerebrospinal Fluid Real-Time Quaking-Induced Conversion Is a Robust and Reliable Test for Sporadic Creutzfeldt-Jakob Disease: An International Study

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    Author
    McGuire, LI; Poleggi, A; Poggiolini, I; Suardi, S; Grznarova, K; Shi, S; de Vil, B; Sarros, S; Satoh, K; Cheng, K; ...
    Date
    2016-07-01
    Source Title
    Annals of Neurology
    Publisher
    WILEY-BLACKWELL
    University of Melbourne Author/s
    Collins, Steven; Sarros, Shannon
    Affiliation
    Medicine and Radiology
    Florey Department of Neuroscience and Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    McGuire, L. I., Poleggi, A., Poggiolini, I., Suardi, S., Grznarova, K., Shi, S., de Vil, B., Sarros, S., Satoh, K., Cheng, K., Cramm, M., Fairfoul, G., Schmitz, M., Zerr, I., Cras, P., Equestre, M., Tagliavini, F., Atarashi, R., Knox, D. ,... Green, A. (2016). Cerebrospinal Fluid Real-Time Quaking-Induced Conversion Is a Robust and Reliable Test for Sporadic Creutzfeldt-Jakob Disease: An International Study. ANNALS OF NEUROLOGY, 80 (1), pp.160-165. https://doi.org/10.1002/ana.24679.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260379
    DOI
    10.1002/ana.24679
    Abstract
    Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice. Ann Neurol 2016;80:160-165.

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