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    Bone geometry of the hip is associated with obesity and early structural damage - a 3.0 T magnetic resonance imaging study of community-based adults

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    Author
    Teichtahl, AJ; Wang, Y; Smith, S; Wluka, A; Zhu, M; Urquhart, D; Giles, GG; O'Sullivan, R; Cicuttini, FM
    Date
    2015-04-30
    Source Title
    Arthritis Research and Therapy
    Publisher
    BMC
    University of Melbourne Author/s
    Giles, Graham
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Teichtahl, A. J., Wang, Y., Smith, S., Wluka, A., Zhu, M., Urquhart, D., Giles, G. G., O'Sullivan, R. & Cicuttini, F. M. (2015). Bone geometry of the hip is associated with obesity and early structural damage - a 3.0 T magnetic resonance imaging study of community-based adults. ARTHRITIS RESEARCH & THERAPY, 17 (1), https://doi.org/10.1186/s13075-015-0631-4.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260398
    DOI
    10.1186/s13075-015-0631-4
    Abstract
    INTRODUCTION: The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions. METHODS: One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010. RESULTS: Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm(3) (95% confidence interval (CI) 20 mm(3) to 98 mm(3), P < 0.01). Greater acetabular depth was associated with an increased risk of cartilage defects (odds ratio (OR) 1.22, 95% CI 1.03 to 1.44, P = 0.02) and bone marrow lesions (OR 1.29, 95% CI 1.01 to 1.64, P = 0.04) in the central region of the femoral head. Lateral centre edge angle was not associated with hip structure. CONCLUSIONS: Obesity is associated with acetabular over-coverage. Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions. Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

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