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    Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat

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    14
    Author
    Falkenberg, KJ; Gould, CM; Johnstone, RW; Simpson, KJ
    Date
    2014-01-01
    Source Title
    Scientific Data
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Johnstone, Ricky; Simpson, Kaylene
    Affiliation
    Sir Peter MacCallum Department of Oncology
    Clinical Pathology
    Metadata
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    Document Type
    Journal Article
    Citations
    Falkenberg, K. J., Gould, C. M., Johnstone, R. W. & Simpson, K. J. (2014). Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat. SCIENTIFIC DATA, 1 (1), https://doi.org/10.1038/sdata.2014.17.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260416
    DOI
    10.1038/sdata.2014.17
    NHMRC Grant code
    NHMRC/1028871
    Abstract
    Identification of mechanisms of resistance to histone deacetylase inhibitors, such as vorinostat, is important in order to utilise these anticancer compounds more efficiently in the clinic. Here, we present a dataset containing multiple tiers of stringent siRNA screening for genes that when knocked down conferred sensitivity to vorinostat-induced cell death. We also present data from a miRNA overexpression screen for miRNAs contributing to vorinostat sensitivity. Furthermore, we provide transcriptomic analysis using massively parallel sequencing upon knockdown of 14 validated vorinostat-resistance genes. These datasets are suitable for analysis of genes and miRNAs involved in cell death in the presence and absence of vorinostat as well as computational biology approaches to identify gene regulatory networks.

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