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dc.contributor.authorFalkenberg, KJ
dc.contributor.authorGould, CM
dc.contributor.authorJohnstone, RW
dc.contributor.authorSimpson, KJ
dc.date.accessioned2021-02-05T01:29:11Z
dc.date.available2021-02-05T01:29:11Z
dc.date.issued2014-01-01
dc.identifier.citationFalkenberg, K. J., Gould, C. M., Johnstone, R. W. & Simpson, K. J. (2014). Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat. SCIENTIFIC DATA, 1 (1), https://doi.org/10.1038/sdata.2014.17.
dc.identifier.issn2052-4463
dc.identifier.urihttp://hdl.handle.net/11343/260416
dc.description.abstractIdentification of mechanisms of resistance to histone deacetylase inhibitors, such as vorinostat, is important in order to utilise these anticancer compounds more efficiently in the clinic. Here, we present a dataset containing multiple tiers of stringent siRNA screening for genes that when knocked down conferred sensitivity to vorinostat-induced cell death. We also present data from a miRNA overexpression screen for miRNAs contributing to vorinostat sensitivity. Furthermore, we provide transcriptomic analysis using massively parallel sequencing upon knockdown of 14 validated vorinostat-resistance genes. These datasets are suitable for analysis of genes and miRNAs involved in cell death in the presence and absence of vorinostat as well as computational biology approaches to identify gene regulatory networks.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGenome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat
dc.typeJournal Article
dc.identifier.doi10.1038/sdata.2014.17
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Data
melbourne.source.volume1
melbourne.source.issue1
melbourne.identifier.nhmrc1028871
dc.rights.licenseCC BY
melbourne.elementsid979054
melbourne.contributor.authorJohnstone, Ricky
melbourne.contributor.authorSimpson, Kaylene
dc.identifier.eissn2052-4463
melbourne.identifier.fundernameidNHMRC, 1028871
melbourne.accessrightsOpen Access


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