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dc.contributor.authorWong, VK
dc.contributor.authorBaker, S
dc.contributor.authorConnor, TR
dc.contributor.authorPickard, D
dc.contributor.authorPage, AJ
dc.contributor.authorDave, J
dc.contributor.authorMurphy, N
dc.contributor.authorHolliman, R
dc.contributor.authorSefton, A
dc.contributor.authorMillar, M
dc.contributor.authorDyson, ZA
dc.contributor.authorDougan, G
dc.contributor.authorHolt, KE
dc.date.accessioned2021-02-05T01:30:12Z
dc.date.available2021-02-05T01:30:12Z
dc.date.issued2016-10-05
dc.identifierpii: ncomms12827
dc.identifier.citationWong, V. K., Baker, S., Connor, T. R., Pickard, D., Page, A. J., Dave, J., Murphy, N., Holliman, R., Sefton, A., Millar, M., Dyson, Z. A., Dougan, G. & Holt, K. E. (2016). An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms12827.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/260422
dc.description.abstractThe population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates. Here we utilize data from whole-genome sequences (WGS) of nearly 2,000 isolates sourced from over 60 countries to generate a robust genotyping scheme that is phylogenetically informative and compatible with a range of assays. These data show that, with the exception of the rapidly disseminating H58 subclade (now designated genotype 4.3.1), the global S. Typhi population is highly structured and includes dozens of subclades that display geographical restriction. The genotyping approach presented here can be used to interrogate local S. Typhi populations and help identify recent introductions of S. Typhi into new or previously endemic locations, providing information on their likely geographical source. This approach can be used to classify clinical isolates and provides a universal framework for further experimental investigations.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAn extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms12827
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume7
melbourne.source.issue1
melbourne.identifier.nhmrc1061409
dc.rights.licenseCC BY
melbourne.elementsid1102911
melbourne.contributor.authorDyson, Zoe
melbourne.contributor.authorHolt, Kathryn
melbourne.contributor.authorDougan, Gordon
melbourne.contributor.authorMulholland, Edward
dc.identifier.eissn2041-1723
melbourne.identifier.fundernameidNHMRC, 1061409
melbourne.accessrightsOpen Access


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