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    The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry.

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    25
    Author
    Christo, S; Bachhuka, A; Diener, KR; Vasilev, K; Hayball, JD
    Date
    2016-05-18
    Source Title
    Scientific Reports
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Christo, Susan
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Christo, S., Bachhuka, A., Diener, K. R., Vasilev, K. & Hayball, J. D. (2016). The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry.. Sci Rep, 6 (1), pp.26207-. https://doi.org/10.1038/srep26207.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260461
    DOI
    10.1038/srep26207
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870632
    Abstract
    Implantable devices have become an established part of medical practice. However, often a negative inflammatory host response can impede the integration and functionality of the device. In this paper, we interrogate the role of surface nanotopography and chemistry on the potential molecular role of the inflammasome in controlling macrophage responses. To achieve this goal we engineered model substrata having precisely controlled nanotopography of predetermined height and tailored outermost surface chemistry. Bone marrow derived macrophages (BMDM) were harvested from genetically engineered mice deficient in the inflammasome components ASC, NLRP3 and AIM2. These cells were then cultured on these nanoengineered substrata and assessed for their capacity to attach and express pro-inflammatory cytokines. Our data provide evidence that the inflammasome components ASC, NLRP3 and AIM2 play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry. The findings of this paper are important for understanding the inflammatory consequences caused by biomaterials and pave the way to the rational design of future implantable devices having controlled and predictable inflammatory outcomes.

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