The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate
AuthorWu, C; Wang, L; Fang, Z; Hu, Y; Chen, S; Sugawara, T; Ye, X
Source TitleMarine Drugs
University of Melbourne Author/sFang, Zhongxiang
AffiliationAgriculture and Food Systems
Document TypeJournal Article
CitationsWu, C., Wang, L., Fang, Z., Hu, Y., Chen, S., Sugawara, T. & Ye, X. (2016). The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate. MARINE DRUGS, 14 (5), https://doi.org/10.3390/md14050095.
Access StatusOpen Access
To elucidate the structure-antioxidant activity relationships of chitosan gallate (CG), a series of CG derivatives with different degrees of substitution (DS's) and molecular weights (MWs) were synthesized from chitosan (CS) and gallic acid (GA) via a free radical graft reaction. A higher MW led to a lower DS of CG. The structures of CG were characterized by FT-IR and ¹H NMR, and results showed that GA was mainly conjugated to the C-2 and C-6 positions of the CS chain. The antioxidant activity (the DPPH radical scavenging activity and reducing power) were enhanced with an increased DS and a decreased MW of CG. A correlation between antioxidant activities and the DS and MW of CG was also established. In addition, a suitable concentration (0~250 μg/mL) of CG with different MWs (32.78~489.32 kDa) and DS's (0~92.89 mg·GAE/g CG) has no cytotoxicity. These results should provide a guideline to the application of CG derivatives in food or pharmacology industries.
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