Transcriptional ontogeny of first trimester human fetal and placental mesenchymal stem cells: Gestational age versus niche.

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    Author
    Ryan, JM; Matigian, N; Pelekanos, RA; Jesuadian, S; Wells, CA; Fisk, NM
    Date
    2014-12
    Source Title
    Genomics Data
    Publisher
    Elsevier BV
    University of Melbourne Author/s
    Wells, Christine
    Affiliation
    Anatomy and Neuroscience
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Ryan, J. M., Matigian, N., Pelekanos, R. A., Jesuadian, S., Wells, C. A. & Fisk, N. M. (2014). Transcriptional ontogeny of first trimester human fetal and placental mesenchymal stem cells: Gestational age versus niche.. Genom Data, 2, pp.382-385. https://doi.org/10.1016/j.gdata.2014.10.016.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260472
    DOI
    10.1016/j.gdata.2014.10.016
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535935
    Abstract
    Early fetal and placental MSCs have translationally-advantageous characteristics compared to later pregnancy MSCs. During the first trimester, the fetus and placenta grow rapidly with divergent developmental requirements, but studies comparing mesenchymal stem cells (MSCs) from different origins have paid little attention to the effect of gestational age over this temporal window. Here we present the transcriptome through first trimester development of MSC isolated from fetal bone marrow (BM) or placental structures. Samples were collected weekly from 8 to 12 weeks. The raw microarray data are available on the ArrayExpress database (www.ebi.ac.uk/arrayexpress) under accession number E-TABM-1224. Additionally, the data have been integrated into the stem cell collaboration platform www.Stemformatics.org. These data provide a valuable resource for developmental biology and stem cell investigation.

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