IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
AuthorAshman, RB; Vijayan, D; Wells, CA
Source TitleClinical and Developmental Immunology
University of Melbourne Author/sWells, Christine
AffiliationAnatomy and Neuroscience
Document TypeJournal Article
CitationsAshman, R. B., Vijayan, D. & Wells, C. A. (2011). IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011, https://doi.org/10.1155/2011/686597.
Access StatusOpen Access
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
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